摘要
目的观察当归挥发油中藁本内酯的镇痛作用及对非细菌性前列腺炎前列腺组织中神经生长因子(NGF)表达的影响。方法共实施3个实验,实验1、2以昆明小鼠为实验对象,用哌替啶为对照药物,分别观察藁本内酯对醋酸致痛镇痛率、热板致痛痛阈值的影响。实验3以前列腺炎模型大鼠为实验对象,用阿司匹林为对照药物,观察藁本内酯对非细菌性前列腺炎前列腺组织中NGF表达的影响。结果实验1、2结果显示,与空白对照组比较,藁本内酯分别可以有效缓解醋酸、热板刺激所引起的小鼠疼痛反应(P<0.01,P<0.05);实验3结果显示,与假手术组比较,藁本内酯能够下调前列腺炎模型大鼠前列腺组织中NGF的表达(P<0.05)。结论藁本内酯具有镇痛作用,并可下调非细菌性前列腺炎前列腺组织中NGF的表达。
Objective To observe abirritation of ligustilide and its influence on NGF of abacterial prostatitis in prostate tissue. Methods Experiment 1 and 2 using kunming mice as experimental objects, pethidine as controlled drugs, the ligustilide influences on analgesia rate of acetic acid pain caused by hot plate pain threshold were observed. Then Experiment 3 used SD rats as experimental object, aspirin as controlled drugs, the influence on the expression of NGF was also observed. Results According to the results of experiment 1 and 2, ligustilide can effectively relieve the pain reaction in mice caused by acetic acid and hot plate. According to the results of experiment 3, it can significantly reduce the NGF expression levels in prostate tissue.Conclusion Ligustilide showed good analgesic anti-inflammatory effect, can also reduce the NGF expression in nonbacterial prostatitis prostate tissue.
出处
《湖南中医药大学学报》
CAS
2014年第9期27-30,65,共5页
Journal of Hunan University of Chinese Medicine
基金
湖南省科技厅科研资助项目(2013FJ6039)
