氨基糖苷类抗生素雾化吸入致不良反应国内外文献报道分析

Analysis on the literatures of adverse drug reactions caused by aerosolized aminoglycoside antibiotics

目的:分析氨基糖苷类抗生素雾化吸入致不良反应的一般规律和特点。方法:检索国内外关于氨基糖苷类雾化吸入致不良反应的个案报道,并进行统计、分析。结果:收集氨基糖苷类雾化吸入引起的不良反应病例共计127例,所致不良反应男性多于女性,呼吸困难为最常见不良反应,通过处理后大部分不良反应好转。结论:应重视氨基糖苷类雾化吸入的安全性,以避免或减少不良反应的发生。

ORIECTIVE To investigate the general rules and characteristics of the adverse drug reactions cause by aerosolized aminoglycoside antibiotics. METItODS The case reports of adverse drug reactions due to aerosolized aminoglycoside treatment published over the world were searched for statistical analysis. RESULTS A total of 127 aerosolized aminoglycoside-induced adverse drug reactions cases were collected, of which males showed higher incidence than females, and the adverse drug reac- tions were mainly dyspnea. Most of the adverse reactions improved after intervention. CONCLUSION More attention should be given to the safety of aerosolized aminoglycoside to avoid or reduce the risk of adverse drug reactions.