复方芩连清解颗粒的质量控制

Qualitative standards for Compound Qinlian Qing particles

目的:建立复方芩连清解颗粒的质量控制方法。方法:采用薄层色谱法对处方中金银花、黄连进行定性鉴别;采用HPLC法对君药黄芩的主要有效成分黄芩苷进行含量测定。结果:在薄层色谱中,与对照药材相应的位置上,检测出相应的特征性斑点,且斑点清晰;黄芩苷的含量测定方法专属性好,阴性无干扰。结论:建立的质量标准专属性较强,方法重复性好,可作为该制剂的质量控制方法。

OBJECTIVE To establish the quality control methods for Compound Qinlian Qing particles. METHODS Honey- suckle and Rhizoma Coptidis were identified by TLC; and determining the content of baicalin which is the main active ingredient of the herbs skullcap by HPLC. RESULTS On the map of TLC, the corresponding characteristic spots were detected on the corresponding positions with the reference drug, and the spots were clear; the method for determining the content of baicalin was very special, and the negative sample was without interference. CONCLUSION The quality standard has a good specificity and the methods have good reproducibility. So the quality control methods can be used as the preparation for Compound Qinlian Qing particles.