云厚朴醇提物中厚朴酚与和厚朴酚降解动力学研究

Study on degradation kinetics of magnolol and honokiol in the ethanol extraction of magnolia rostrata

目的研究云厚朴醇提物中厚朴酚、和厚朴酚在贮放、浓缩、干燥工序中的降解规律。方法通过高效液相色谱法测定云厚朴醇提物中厚朴酚与和厚朴酚在不同贮放、浓缩、干燥条件下的含量变化,得出降解规律。结果云厚朴醇提液在室内常温下贮放20天,和厚朴酚、厚朴酚含量基本不变;云厚朴醇提液在60℃浓缩和干燥,厚朴酚及和厚朴酚的降解动力学符合零级反应,在100℃降解较快。结论云厚朴醇提液在室温下贮放20天基本稳定,但是不能长时间在高温条件下浓缩、干燥,以免有效成分损失,在100℃干燥时降解较快,制剂生产中应避免醇提液长时间高温干燥、浓缩。

Objective To study degradation law of magnolol and honokiol in the ethanol extraction of magnolia rostrata during storage,concentrating and drying. Methods To find the law of degradation,the contents of magnolol and honokiol were tested by high performance liquid chromatography under storage,concentrating and drying conditions. Results The content of magnolol and honokiol in the ethanolextraction remained almost the same within 20 days when kept indoors. The degradation reactions of magnolol and honokiol were zero-order when concentrating at 60℃ and drying. When drying at 100℃,the rate of degradation was faster. Conclusion Magnolol and honokiol in the ethanol extraction are almost stable within 20 days when kept indoors,but can not be dried and concentrated longer under higher temperature.The rate of degradation is faster when drying at 100℃. In order to ensure the preparation quality,higher temperature and longer time should be avoided during drying and concentrating for the ethanol extraction of magnolia rostrata.