赖氨酰氧化酶与盆腔器官脱垂的研究

Research on lysyl oxidase and pelvic organ prolapse

盆腔器官脱垂(POP)是常见的妇产科疾病,但其发病机制尚不明确。目前研究表明,POP的发生与盆底结缔组织结构及功能完整性被破坏有关,而盆底结缔组织细胞外基质(ECM)的主要成分是弹性蛋白和胶原蛋白,弹性蛋白和胶原蛋白的含量和结构的改变可引起组织弹性降低,盆底结构松弛。赖氨酰氧化酶(LOX)能催化弹性纤维的聚合形成共价交联,增加细胞外基质的稳定性,故推测LOX表达的改变在POP的发生、发展中可能起一定作用。

Pelvic organ prolapse （POP）is a common gynecopathy,but the pathogenesis of POP is obscure up to now.Recent studies have shown an association between POP and the destroy of structural and functional integrity of pelvic connective tissue.The main proteins composing pelvic connective tissue extracellular matrix （ECM）are elastin and collagen.Elastin and collagen contents and structural changes can cause the decreasing of tissue elasticity and the relaxation of pelvic floor structure.Lysyl oxidase （LOX）can catalyze the polymerization of elastic fibers forming covalent crosslinking to increase the stability of EMC,so it is supposed that the change of LOX expression may make a certain contribution to the occurrence and development of POP.