骨髓增生异常综合征向急性白血病转化相关微小RNA的研究进展

Research progress of microRNA in the transformation from myelodysplastic syndromes into acute leukemia

微小RNA（miRNA）是一种长度为18～25个核苷酸的内源性非编码小RNA分子,发挥着广泛而重要的调控功能.miRNA的异常表达可以导致许多血液系统疾病.骨髓增生异常综合征（MDS）是一组以无效造血、病态造血及高风险向急性髓系白血病（AML）转化为特点的高度异质性疾病,20％～30％的MDS患者可能向AML进展.miRNA在MDS的发生、发展及疾病转归中起了重要作用.文章就近年MDS向AML转化相关miRNA的研究进展作一综述.

microRNA （miRNA） is a kind of 18 to 25 nucleotide non coding RNAs,which plays an important role in various ways.The abnormal miRNA expression patterns lead to many diseases of hematopoietic system.Myelodysplasitc syndromes （MDS） comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis,bone marrow dysplasia and variable propensity of transformation to acute myeloid leukemia （AML）.20 ％-30 ％ MDS patients may progress to AML.miRNA plays a key role in the develpoment,advance and prognosis of MDS.In this paper,the related miRNAs in the transformation from MDS into AML were reviewed.