服用止咳药水或海洛因成瘾者心电图及临床资料分析

Analysis of electrocardiogram and clinical data of people taking cough syrup or addicted to heroin

目的调查服用止咳药水或海洛因成瘾者心电图及临床资料。方法收集我院成瘾医学科选择450例止咳药水或海洛因成瘾者,收集时间为2007年12月-2011年12月,按服用止咳药水或海洛因的不同分为两组,止咳药水组200例,海洛因组250例,正常健康人为对照组200例。记录患者空腹血糖、总胆固醇、血甘油三酯、血低密度脂蛋白胆固醇、血高密度脂蛋白胆固醇、血压、心电图。结果与止咳药水组、海洛因组比较,对照组血红蛋白、总胆固醇、甘油三酯、收缩压、舒张压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇较高,差异有统计学意义（P〈0.05）;与止咳药水组比较,海洛因组血红蛋白、总胆固醇、甘油三酯、收缩压、舒张压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇较低,差异有统计学意义（P〈0.05）;对照组窦性心动过缓、窦性心动过速、房性期前收缩、室性期前收缩、左前分支传导阻滞、左后分支传导阻滞、房室传导阻滞、ST-T改变、肢体导联低电压、QT间期延长改变、完全性右束支传导阻滞、不完全性右束支传导阻滞发病率最低,海洛因组最高,差异有统计学意义（P〈0.05）。结论三组中,海洛因组的心肌、生化损害最为严重,止咳药水组也有不同程度损害。我们应加强禁毒宣传工作,提高对毒品危害的认识。

Objective To investigate the electrocardiogram and clinical data of people taking cough syrup or addicted to heroin. Methods A total of 450 people took cough syrup or addicted to heroin who were treated in the addiction medicine department of our hospital were collected from December 2007 to December 2011 and divided into two groups according to the addition type, with 200 cases in the cough syrup group and 250 cases in the heron group, and the control group consists of 200 normal healthy persons. The patients＇ fasting glucose, total cholesterol, serum triglycerides,blood low-density lipoprotein cholesterol, blood high-density lipoprotein cholesterol, blood pressure and electrocardiogram were recorded. Results The cough syrup group compared with the heroin group, the control group had higher hemoglobin, total cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol and low density lipoprotein cholesterol, with statistically significant differences（P〈0.05）; Compared with the cough syrup group, the heroin group had lower hemoglobin, total cholesterol, triglycerides, systolic blood pressure,diastolic blood pressure, high-density lipoprotein cholesterol and low density lipoprotein cholesterol, with statistically significant differences（P〈0.05）; The control group had the lowest incidences of bradycardia, sinus tachycardia, premature atrial contraction, premature ventricular contraction, left anterior branch conduction block, left posterior branch conduction block, atrioventricular conduction block, ST-T change, limb leads low voltage, QT interval prolongation change, complete right bundle branch block and incomplete right bundle branch block, and the heroin group had the highest incidences, with statistically significant differences（P〈0.05）. Conclusion Of the 3 groups, the heroin group has the severest myocardial and biochemical damage and the cough syrup group also has varying degrees of damage.Anti-drug publicity should be strengthened in order to improve the awareness of drug harm.