舌下含服粉尘螨滴剂治疗不同年龄组变应性鼻炎的疗效评估

Efficacy of sublingual immunotherapy with dermatophagoides farianae drops in the different age groups with allergic rhinitis

目的评估舌下含服粉尘螨滴剂治疗不同年龄组变应性鼻炎患者的疗效差异。方法回顾性分析了接受舌下特异性免疫疗法治疗1年以上的117例AR患者,根据就诊年龄分为儿童组（6-14岁,35例）、青年组（15-35岁,45例）和中老年组（36-66岁,37例）,评估三组患者治疗前、治疗半年、1年后的鼻部症状评分、药物评分和体征评分的变化。结果与治疗前相比,三组患者的鼻部症状评分、药物评分以及体征评分在治疗半年、1年后有显著降低,差异均有统计学意义（P〈0.05）;治疗1年后与治疗半年相比,除儿童组的症状得到持续改善,差异有统计学意义（q=3.05,P〈0.05）,其他差异均无统计学意义（P〉0.05）。儿童组、青年组和老年组的鼻部症状评分、药物评分以及体征评分在各个时间点差异均无统计学意义（P〉0.05）。结论舌下含服粉尘螨滴剂对不同年龄组的AR患者具有显著疗效,且不同年龄组间的疗效相近。

Objective To evaluate the efficacy of the sublingual immunotherapy with Dermatophagoides farianae drops on different age groups. Methods The efficacy of 117 patients with AR received SLIT treatment for more than one year were retrospectively analyzed. These patients were divided into three groups according to the age, children group（6-14 year old, 35 patients）, youth age group（15-35 year old, 45 cases） and middle-aged group（36-66 year old, 37 patients）. Before and SLIT treatment for half one year, one year, symptom score, medication score and signs score were evaluated. Results After SLIT treatment for half a year and one year, the symptom score, medication score and signs score in these patients significantly reduced compared with before（P〈0.05）. Compared with after half a year treatment,the symptom score of children group significantly reduced（q=3.05, P〈0.05）, and other indicators were not statistically significant（P〉0.05）. The symptom score, medication score and signs score among three age groups were not statistically significant（P〉0.05） at all the time points. Conclusion Dermatophagoides farinae drops on allergic rhinitis can play a significant and similar effect in the different age groups.