乳腺癌组织IGFBP-6的表达及意义

EXPRESSIONS AND SIGNIFICANCE OF IGFBP-6 IN BREAST CANCER

目的:探讨胰岛素样生长因子结合蛋白-6(IGFBP-6)在乳腺癌组织中的表达及其与乳腺癌临床病理特征的关系。方法:采用免疫组织化学SP法检测60例乳腺癌、30例乳腺纤维腺瘤、20例乳腺增生症组织IGFBP-6的表达。结果:乳腺癌、乳腺纤维腺瘤和乳腺增生症组织中IGFBP-6表达水平不同(P<0.05)。乳腺癌组织IGFBP-6的表达与年龄、组织学类型无关(P>0.05),与肿瘤大小及淋巴结转移有关(P<0.05)。结论:IGFBP-6可能在乳腺癌的发生发展过程中具有重要作用。

Objective：To investigate the expression ofinsulin-like growth factor binding protein-6（IGFBP-6） in breast cancer,and the relationship between IGFBP-6 expression and clinicopathological features of breast cancer.Methods：SP immunohistochemical staining was used to detect the IGFBP-6 expression in 60 cases breast cancer,30 cases breast fi broadenoma and 20 cases cyclomastopathy.Results：The expression of IGFBP-6 expression in breast cancer,breast fi broadenoma and cyclomastopathy was different（P 0.05）.In breast cancer,the IGFBP-6 expression had no relations with age and histological type（P 0.05）;but was related to size of tumor and lymph node（P 0.05）.Conclusions：IGFBP-6 may play important role in development of breast cancer.