幽门螺杆菌感染与肠易激综合征相关性的Meta分析

Meta-analysis on relationship between Helicobacter pylori infection and irritable bowel syndrome

目的采用meta分析的方法对国内外已发表的有关幽门螺杆菌（H.pylori）感染与肠易激综合征（IBS）相关性的研究进行系统评价。方法以＂幽门螺杆菌＂和＂肠易激综合征＂为检索词,检索PubMed、Elsevier、Springer-Link、CNKI、WanFang Data、CBM、Google学术搜索,并追溯参考文献和引文进行了全面的文献检索。根据文献纳入与排除标准筛选文献并评价质量,采用Review Manager 4.3、Stata 12.0软件进行meta分析、发表偏倚的评估及敏感性分析。结果本研究共纳入文献14篇,经meta分析,肠易激综合征组共1 473例,对照组共1 739例,OR=1.62,95%CI：1.22～2.14,P〈0.001。漏斗图、失安全系数分析及Begg法计算结果均显示发表偏倚较小。敏感性分析表研究明结果稳定可靠。结论幽门螺杆菌感染是肠易激综合症的危险因素。

Objective To evaluate the relationship between Helicobacter pylori （H. pylori） infection and irritable bowel syndrome（IBS） using meta-analysis among domestic and foreign published articles. Methods Literatures on the relationship between H. pylori infection and IBS were searched in PubMed, Elsevier, Springer-Link, CNKI, WanFang Data, CBM and Google. Searching terms ＂Helicobacter pylori＂ and ＂irritable bowel syndrome＂ were used. Meanwhile, relative journals were referved to. According to the inclusion and exclusion criteria, data were extracted and the methodological quality was evaluated. Then the meta-analysis was conducted using RevMan 4. 3 and Stata 12. 0 softwares, and the publica- tion bias and sensitivity were evaluated at the same time. Results A total of 14 studies were included, which involved 1 473 cases and 1 739, and OR = 1.62, 95% CI： 1.22-2. 14, P 〈 0. 001. Funnel plot, fail-safe number calculation and quantification by Begg method suggested little publication bias. The sensitiviiy analysis showed that outcome of this study was stable and reliable. Conclusions Helicobacter pylori infection is a probable risk factor of irritable bowel syndrome （IBS）.