CK-MB、TNI、IL-6与有机磷中毒性心肌炎关系的探讨

An exploratory study on relationship between levels of CK- MB,TNI and IL-6 with toxic myocarditis caused by organophosphate

目的探讨有机磷中毒性心肌炎患者肌钙蛋白(TNI)、肌酸激酶同工酶(CK-MB)、白介素-6(IL-6)水平的变化情况。方法选择有机磷中毒性心肌炎患者30例为研究对象,同期健康体检者30例为对照组。两组患者均空腹抽静脉血3 ml,送实验室检测患者CK-MB、TNI、IL-6水平,并进行组间比较。结果中毒组患者CK-MB、TNI、IL-6水平明显高于对照组,差异有统计学意义(P<0.05);中毒患者中,由轻度到重度,CK-MB、TNI、IL-6水平逐渐升高,各亚组间比较,差异有统计学意义(P<0.05)。结论 CK-MB、TNI、IL-6三者联合可有效反映有机磷中毒性心肌损害程度,临床对于CK-MB、TNI、IL-6明显升高的患者,应及时对应治疗,尽量改善患者预后情况。

Objective To explore the changes in levels of CK-MB,TNI（ troponin）,IL-6 in patients with toxic myocarditis caused by organophosphate. Methods A total of 30 patients with toxic myocarditis caused by organophosphate in this hospital were selected for this study, and 30 healthy persons in the same period were selected as control group. Three ml of fasting blood were drawn from each patient of these two groups,and levels of CK-MB,TNI and IL-6 were detected and their results were compared between these 2 groups. Results Levels of CK-MB,TNI and IL-6 in patients of poisoned group were significantly higher than those of control group,the difference between these two groups was statistically significant. The levels of CK-MB,TNI and IL-6 were gradually increased following with the degree of poisoning from mild to severe, and the difference was statistically significant. Conclusion CK-MB and TNI as specific markers for myocardial impairment,they can reflect the degree of toxic reaction for myocardial impairment,IL-6 can induce myocardial impairment through inflammation,hence it can also be applied as indicator for monitoring the degree of myocardial impairment;the combined examination of these three markers can effectively reflect the extent of myocardial impairment caused by toxic organophosphate in order to guide the treatment.