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松弛素生物学作用研究进展 被引量:3

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摘要 1930年,Fevold和Hisaw等人从母猪的黄体提取了可以松弛耻骨韧带的物质,命名为松弛素( Relaxin, RLX)。RLX主要来源于妊娠黄体的多肽类激素,分子结构类似胰岛素。目前已发现体内多种组织分泌RLX,其中有的进入血液循环作为全身性激素,有的不进入循环只作为局部激素起自分泌或旁分泌作用。RLX有利于妊娠维持和分娩,对非生殖系统的作用包括抗纤维化、舒张血管以及促进组织愈合;RLX作用于细胞外基质,维持组织器官稳态起重要作用。近年研究还发现RLX与许多肿瘤的发生有一定关系。本研究就近年来RLX的生物学作用研究做一综述。
出处 《临床和实验医学杂志》 2014年第19期1651-1653,共3页 Journal of Clinical and Experimental Medicine
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