基于LPC2478的三通道静脉麻醉输注系统设计

The design based on microcontrollers LPC2478 for target controlled infusion of three channel

目的:开发一种以LPC2478为控制核心的智能化三通道静脉麻醉药代动力学给药控制系统,以实现临床静脉麻醉精确、科学地给药。方法:采用两颗ARM微控制器LPC2478作为系统控制核心,分别完成药代动力学模型计算、直流电机驱动及外围数据采集和处理。结果:完成基于LPC2478三通道静脉麻醉输注系统的软硬件设计,系统根据患者体重、身高和性别,运用药动学模型实现静脉麻醉给药由粗放式向精细化、智能化给药。测试表明三通道静脉麻醉控制输注系统结构紧凑,密闭式环境下稳定运行,临床应用异丙酚、利多卡因血药浓度测定值与目标浓度值两者有良好的相关性,且与目标浓度的变化一致,二者之间的误差<25%。结论:采用现代嵌入式技术通过药代动力学模型实现对给药速率的自动控制,降低了麻醉药物不良反应,提高了用药的安全性。

Objective： To develop an intelligent three-channel intravenous anesthetics target infusionsystem by used LPC2478 as control core, in order to realize accurate and scientific clinical intravenousanesthesia. Methods： Using two ARM microcontrollers LPC2478 as the control core, completedpharmacokinetic model calculation, DC motor driver and peripheral data acquisition and processing.Results： A large number of tests show that system has high control accuracy, reliable operation,can meet the clinical needs. Realize the software and hardware design of three-channel intravenousanesthesia infusion system based on LPC2478. According to weight, height and gender of patient,realize the intravenous anesthesia drug delivery from the extensive to refining and intelligent based on pharmacokinetic model. The tests showed that the three-channel intravenous anesthesia control infusion system has compact structure. It can stable operate in the closed environment. The clinical application showed that measured value of blood drug concentration of propofol and lidocaine have good correlation with the target value, and the change is consistent, the error less than 25%. Conclusion： Based on the pharmacokinetic model and modern embedded technology, it can realize the automatic control of the drug delivery rate. This method can reduce adverse reactions of the anesthetic drug, and improve the safety of medication.