鼠神经生长因子联合椎旁阻滞技术治疗肺癌并发带状疱疹神经痛的临床研究

Research on effect of mouse nerve growth factor combined with paravertebral block on lung cancer associated herpes zoster neuralgia

目的：分析鼠神经生长因子联合椎旁神经根组织在肺癌合并带状疱疹神经痛中的应用价值,为临床诊疗提供参考。方法：将62例肺癌合并带状疱疹神经痛的患者随机分为观察组和对照组,每组31例。观察组给予鼠神经生长因子联合椎旁神经根阻滞治疗;对照组给予加巴喷丁联合椎旁神经根阻滞治疗。观察两组患者治疗前及治疗后1周、2周、3周、4周的视觉模拟评分（VAS）及治疗效果。结果：治疗前,两组患者VAS无显著差异,治疗后1-4周,观察组患者VAS均低于对照组,差异有统计学意义（t=5.885,t=8.566,t=6.659,t=8.751;P〈0.05）;观察组有效31例（占96.8%）,对照组有效25例（占80.6%）,观察组总有效率高于对照组,差异有统计学意义（x^2=4.47,P〈0.05）。结论：鼠神经生长因子联合椎旁神经根治疗肺癌合并带状疱疹神经痛的有效率为96.8%,且不增加不良反应的发生,是安全、有效的治疗方法,值得临床借鉴。

Objective： To analyze the clinical value of mouse nerve growth factor combined with paravertebral block on lung cancer associated herpes zoster neuralgia, and prefer a portable diagnosis and treat. Methods： The patients were collected from our hospital during the year January 2011 to April 2014. Sixty-two patients with lung cancer associatedherpes zoster neuralgia were divided into two groups： Observation group（n=31） and Control group（n=31）. The observation group receiving mouse nerve growth factor and paraertebral block anesthesia, while the control group were receiving gabapentin and paraertebral block anesthesia. Visual analogue scale and curative effect were assessed at before and after treatment at the weak 1, weak 2, weak 3, we4 k 4. Results： There were no significant statistic difference on VAS score before treatment between the two groups（P〉0.05）, while there were significant difference between two group in VAS score after 1-4 weak＇ treatment（t=5.885, t=8.566, t=6.659, t=8.751, P〈0.05）. The effective rate of observation group was 96.8%, while the control group was 80.6%, there were significant difference between the two group（x^2=4.47, P〈0.05）. Conclusion： The total Effective rate of mouse nerve growth factor combined with paravertebral block on lung cancer associated herpes zoster neuralgia was 96.8%, which was safe and reliable and was worthy of clinical practice.