慢性阻塞性肺疾病与急性支气管炎肺功能的对比研究

The comparable study of lung function between patients with chronic obstructive pulmonary disease and patients with acute bronchitis

目的探讨脉冲振荡法(IOS)在慢性阻塞性肺疾病(COPD)、急性支气管炎的检测意义。方法选择100例COPD患者、100例急性支气管炎患者与正常对照者100例行常规肺通气功能及IOS检测。观察VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV;Fres、Zrs、R5、R20、R35、X5、Rc、Rp。结果 COPD组与正常组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX、MVV明显降低,P<0.05;Zrs、Fres、R5、R35、X5、R20、Rp明显升高,P<0.05。急性支气管炎组与正常组比较,VC、FVC、FEV1%、MVV明显降低,P<0.05;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。COPD组与急性支气管炎组比较,VC、FVC、FEV1%、FEV1/FVC、MMEF、VMAX明显降低,P<0.01;Zrs、Fres、R5、R20、R35、X5、Rp明显升高,P<0.01。结论 COPD存在阻塞性和限制性通气功能障碍,急性支气管炎存在限制性通气功能障碍;COPD、急性支气管炎均存在总气道阻力、周边气道阻力、周边弹性阻力异常升高。COPD气道阻力升高更明显。

Objective To explore the clinical application value of impulse oscillometry （IOS） in patients with chronic obstructive pulmonary disease （COPD） and acute bronchitis. Methods To compare the parameters of pulmonary ventilation function with the results of respiratory impedance measured by impulse oscillometry in 100 patients with COPD group, 100 patients with acute bronchitis and 100 healthy adults.To observe VC, FVC, FEV1%, FEV1/FVC, MMEF, VMAX, MVV, Fres, Zrs, R5, R20, R35, X5, Rc, Rp. Results There were significant decrease in VC, FVC, FEV1%, FEV1/FVC, VMAX, MVV, P＆lt;0.05. There were significant rise in Zrs, Fres, R5, R35、X5, R20, Rp, P＆lt;0.05 in COPD group compared with normal group. There were decrease in VC, FVC, FEV1%, MVV, P＆lt;0.05;there were significant rise in Zrs, Fres, R5, R20, R35, X5, Rp, P＆lt;0.01 in acute bronchitis group compared with normal group. There were significant decrease in VC, FVC, FEV1%, FEV1/FVC, VMAX, there were significant rise Zrs, Fres, R5, R20, R35, X5, Rp, P＆lt;0.01 in COPD group compared with acute bronchitis group. Conclusion There are obstructive and limited ventilation damage in COPD; There are limited ventilation damage in acute bronchitis group.There are higher all airway resistance and peripheral airway resistance and peripheral reflex resistance in COPD compared with acute bronchitis group.