系统性红斑狼疮的胃肠道损害

Gastrointestinal involvement of systemic lupus erythematosus

系统性红斑狼疮（SLE）是一种系统性自身免疫性疾病,可以累及多个系统.相对于其他受累的系统,胃肠道受累并未受到重视.SLE的胃肠道损害因临床表现多种多样,且缺乏特异性,易与药物的胃肠道不良反应相混淆,而不能得到准确而及时的诊断.但有些SLE相关的胃肠道受累如未得到恰当的治疗可能危及生命.现对SLE常见的胃肠道损害,包括食管及胃受累、狼疮性肠系膜血管炎、狼疮性胰腺炎、狼疮性腹膜炎、假性肠梗阻、蛋白丢失性肠病、肝脾受累的临床表现,诊断和治疗进行阐述.以帮助临床医师更好地认识SLE的胃肠道损害,提高对该类疾病的重视程度,以期得到准确、及时的诊断和治疗.

Systemic lupus erythematosus（SLE） is an autoimmune inflammatory disease,virtually every system and organ can be affected.Gastrointestinal manifestations of SLE attract far less attention than the other major organ involvements.Gastrointestinal manifestations of these diseases often can＇t be diagnosed early and correctly,because the clinical manifestation varies and often nonspecific,and often confused with the side effect of medicine.But SLE related gastrointestinal involvement is clinically important because some cases can be life-threatening if not treated promptly.This paper reviews the common SLE gastrointestinal involvements,including the diagnosis and treatment of esophageal and gastric involvement,lupus mesenteric vasculitis,lupus pancreatitis,lupus peritonitis,pseudo-obstruction,proteinlosing gastroenteropathy,and hepatic involvement,to improve the recognition of gastrointestinal manifestations,and make an early and accurate diagnosis so that appropriate treatment along with prognosis can be made.