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ERCC 1基因多态性在胃癌中的研究

ERCC1 gene polymorphism in gastric cancer
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摘要 作为核酸损伤修复过程的重要成员，切除修复交叉互补基因1（ERCC1）的表达情况与胃癌的发生发展密切相关。研究发现，ERCC1基因的多态性会改变该基因自身的表达，并对铂类化疗药物的敏感性和疗效产生影响，通过对基因多态性的检测可以指导胃癌患者的个体化化疗。 As a crucial part of the DNA damage repair process,the expression of excision repair cross-complementing group 1 （ERCC1 ）is closely related to the genesis and development of gastric cancer.Studies find that ERCC1 gene polymorphism can alter the expression of the gene itself,which affects the sensitivity and efficacy of platinum-based chemotherapy.Therefore,the detection of ERCC1 polymorphism may guide the indi-vidualized chemotherapy of the patients with gastric cancer.
作者 田源 单泽志 彭佳远 汪昱
机构地区 上海交通大学附属第六人民医院普外科
出处 《国际肿瘤学杂志》 CAS 2014年第9期666-668,共3页 Journal of International Oncology
关键词 胃肿瘤 多态性 单核苷酸 切除修复交叉互补基因1 Stomach neoplasms Polymorphism, single nucleotide ERCC1
分类号 R735.2 [医药卫生—肿瘤]
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国际肿瘤学杂志
2014年 第9期

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