B超联合癌抗原199和Osteopont检测在胰腺癌早期诊断中的价值

Clinical value of B-type ultrasonography combined with serum levels of OPN and CA199 in the early pancreatic adenocarcinoma

目的观察B超检查、血清骨桥蛋白(OPN)和癌抗原199(CA199)联合检测对胰腺癌早期诊断的价值。方法采用电化学发光方法和ELISA法检测114例胰腺癌和80例健康受试者血清中CA199、OPN水平,患者术前均经B超检查了解胰腺情况。结果胰腺癌患者血清中CA199、OPN含量显著高于健康对照组(P<0.01)。本实验OPN、CA199、B超检测的敏感性分别为81.6%、78.2%及74.9%。OPN+CAl25+B超联合检测的敏感性为93.6%,OPN+CA199+B超联合检测较CA199、OPN及B超单独检测敏感性高(P<0.05)。结论B超联合CA199和OPN检测可提高胰腺癌诊断的敏感性,在胰腺癌早期诊断中具有重要的临床价值,可弥补肿瘤标志物单独检测的不足。

【Objective】To explore the early diagnostic value of B-ultrasound combined with osteopontin（OPN）and CA199 in patients with pancreatic adenocarcinoma. 【Methods】The serum levels of OPN and CA199 were detected in 114 patients with pancreatic adenocarcinoma and 80 healthy subjects by the electrochemical uminescence method and ELISA, and the Pancreas condition was examined by B-type ultrasonography.【Results】Compared with healthy subjects, the serum levels of OPN and CA199 in patients with pancreatic adenocarcinoma significantly increased（P〈0.01）. The sensitivities of OPN, CA199 and B ultrasound were 81.6%, 78.2% and 74.9%, respectively.The sensitivity of B ultrasound combined with OPN and CA199 detection was 93.6%. The semitivity of combined detection was higher than that by single detection of OPN, CA199, or B ultrasound（P〈0.05）.【Conclusions】Combined detection of B-type ultrasonography and serum levels of OPN and CA199 could increase the diagnostic sensitivity, and it is important in the early diagnosis of pancreatic adenocarcinoma.