干扰素治疗老年丙型病毒性肝炎的疗效探析

The Effect of Interferon in Treatment of Elderly Patients with Viral Hepatitis C

目的研究干扰素治疗老年丙型病毒性肝炎的临床效果。方法选取45例老年丙肝患者与35例中青年丙肝患者,分为老年组与中青年组,比较两组患者不同抗病毒时间HCVRNA阴转率情况以及不良反应发生率情况。结果病毒阴转率比较无统计学意义;抑郁、心电图异常以及白细胞计数降低等不良反应发生情况比较具有统计学意义。结论干扰素治疗老年丙肝患者效果良好,但在治疗6个月后,应依据治疗效果及不良反应选择是否继续用药。

Objective To study the clinical effect of interferon in treatment of elderly patients with viral hepatitis C. Methods 45 cases of elderly patients with hepatitis C and 35 cases of young patients with hepatitis C, were divided into aged group and young group, compared two groups of patients with different antiviral time HCV RNA negative conversion rate and the adverse reaction incidence. Results The virus negative conversion rate showed no statistical significance. The difference of incidence of depression, abnormal electrocardiogram and white blood cell counts decreased and adverse reactions in two groups had statistical significance. Conclusion The effect of interferon treatment in elderly patients with hepatitis C is good, but after 6 months of treatment, it should be based on the treatment effect and adverse reaction to choose whether or not to continue the medication.