抑郁症患者血浆瘦素水平与抗抑郁疗效的相关性研究

Correlation between plasma leptin level and antidepressant curative effect in depressive patient

目的:探讨血浆瘦素水平与抗抑郁疗效的相关性。方法:对43例抑郁症患者采用汉密尔顿抑郁量表24项(HAMD)、Beck绝望量表(BHS)评定抑郁严重程度;测定患者服药前及治疗6周血浆瘦素水平,并以40例体检职工为对照组。结果:不同药物治疗亚组在治疗前后血浆瘦素水平之间差异均无统计学意义(P>0.05)。抑郁症组治疗前血浆瘦素水平[(7.0±3.5)ug/L]显著低于治疗后[(12.8±5.4)ug/L])及对照组[(13.4±6.7ug/)L])(P均<0.01),而抑郁症组治疗后血浆瘦素水平与对照组比较差异无统计学意义(P>0.05)。治疗前血浆瘦素水平与治疗前HAMD、BHS评分呈负相关(r值分别为-0.51、-0.53,P均<0.01);治疗6周血浆瘦素水平与6周HAMD、BHS分呈负相关(r值分别为-0.45、-0.44,P均<0.01);血浆瘦素水平的变化值与HAMD、BHS分的变化值呈负相关(r值分别为-0.40、-0.38,P均<0.01)。结论:瘦素水平变化与抗抑郁疗效相关,提高血浆瘦素水平的药物可能是一种潜在的新型抗抑郁剂。

Objective：To explore the correlation between the plasma leptin level and antidepressant cur-ative effect. Method：Fouty-three patients with depression were evaluated the severity of symptoms by Hamil-ton depression rating scale-24 items（HAMD）and Beck hopelessness scale（BHS）. Forty medical staffs were selected as health control group. Plasma leptin level was detected twice for everyone,before taking pills and after 6 weeks treatment. Results：There were no significant difference between different drug sub groups before and after 6 weeks（P 〉 0. 05）. In depression group,plasma leptin level before taking pills[（7. 0 ± 3. 5）ug/ L]was significantly lower than after 6 weeks treatment[（12. 8 ± 5. 4）ug/ L]as well as the control group[（13. 4 ± 6. 7）ug/ L]（all P 〈 0. 01）;after 6 weeks treatment,there was no difference between depressive patient and the control group（P 〉 0. 05）. Before treatment,plasma leptin level showed a negative correlation with scores HAMD and BHS（r = - 0. 51,r = - 0. 53;all P 〈 0. 01）;after 6 weeks treatment,they also had a negative correlation （r = - 0. 40,r = - 0. 38,all P 〈 0. 01）. There was a significantly negative correlation between plasma leptin level and HAMD、BHS scores difference（r = - 0. 40,r = - 0. 38,all P 〈 0. 01）. Conclusion：The change of plasma leptin level has a significant correlation with the antidepressant curative effect;the drug that can increase plasma leptin level may be a potential new antidepressant.