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α7烟碱型乙酰胆碱受体在阿尔茨海默病中的作用 被引量：1

Effects of alpha 7 nicotinic acetylcholine receptors in Alzheimer's disease
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摘要 阿尔茨海默病(AD)是全球老年人的主要致残、致死疾病之一。淀粉样蛋白(Aβ)级联学说是其重要发病机制之一。α7烟碱型乙酰胆碱受体(α7nAChR)在AD发病、防治等方面都发挥着重要作用。本文就α7nAChR结构、分布及其在AD中的作用加以阐述。 Alzheimer’s disease （AD）is one of the major disabling and lethal diseases for aged people around the world.Beta-amyloid protein （Aβ）cascade hypothesis is one of the important mechanisms of pathogenesis,in which Alpha 7 nicotinic acetylcholine receptor （α7nAChR）plays an important role in the prevention and treatment of AD.This paper reviewed the structure and distribution ofα7nAChR,and its role in AD.
作者 钱亦华
机构地区 西安交通大学医学部人体解剖与组织胚胎学系
出处 《国外医学（医学地理分册）》 CAS 2014年第3期179-183,共5页 Foreign Medical Sciences：Section of Medgeography
基金 国家自然科学基金资助项目(No.81071035) 陕西省科技攻关(No.2005K13-G2) 陕西省卫生厅资助项目(No.08E05)
关键词 α7 烟碱型乙酰胆碱受体 阿尔茨海默病 alpha 7 nicotinic acetylcholine receptor Alzheimer’s disease
分类号 R113 [医药卫生—公共卫生与预防医学]
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参考文献56

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国外医学（医学地理分册）
2014年 第3期

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