胃溃疡患者焦虑状态与TIFF1及EGF水平关系分析

Correlation of gastric ulcer patients' anxiety status and TIFF1 and the EGF levels

目的探讨胃溃疡患者不同焦虑状态与TIFF1及EGF水平的关系并进行相关性分析。方法对入选的胃溃疡患者95例采用汉密尔顿焦虑量表(HAMA)进行评估,分为明显焦虑组、焦虑组及无焦虑组,每组分别有41、32、22例。入选后分别行TIFF1及EGF、PGⅠ、PGⅡ测定。结果焦虑组HAMA评分、TIFF1及EGF较无焦虑组差异显著(P<0.05),明显焦虑组HAMA评分、TIFF1及EGF较无焦虑组差异显著(P<0.05)。焦虑组PGⅠ、PGⅠ/PGⅡ较无焦虑组显著下降(P<0.05),明显焦虑组PGⅠ、PGⅠ/PGⅡ较无焦虑组及焦虑组均存在有显著性差异(P<0.05)。HAMA与TIFF呈显著负相关,与PGⅠ、PGⅠ/PGⅡ呈显著负相关(P<0.05)。结论焦虑状态是的影响胃溃疡患者TIFF1及EGF水平的重要因素,焦虑状态加重将直接影响到对胃黏膜损伤的修复能力。

Objective To investigate the correlation between gastric ulcer patients’anxiety status and TIFF1 and the EGF levels.Methods 95 cases of gastric ulcer patients were enrolled and evaluated by Hamilton anxiety scale （HAMA）,divided into obvious anxiety,anxiety and anxiety group,there were 41,32,22 cases respectively. TIFF1 and EGF,PGⅠ,PGⅡ were determined.Results HAMA scores,TIFF1 and EGF of anxiety group and less anxiety group showed significant difference （P〈0.05）,HAMA scores,TIFF1 and EGF of obvious anxiety group than less anxiety group showed significant difference （P〈0 .0 5 ）.PGⅠ,PGⅠ/PG Ⅱ of anxiety group than less anxiety group decreased significantly （P〈0 .0 5 ）,PGⅠ,PGⅠ/PGⅡ of obvious anxiety group than less anxiety and anxiety group showed significant differences （P〈0.05）.HAMA and TIFF showed significant positive correla-tion,PGⅠ,PGⅠ/PG Ⅱ showed significantly negative correlation （P〈0.05）.Conclusion Anxiety state is the important factors that affect gastric ulcer patients TIFF1 and EGF levels,increasing anxiety state will directly affect ability to repair damage.