微囊藻毒素生物合成基因及其功能研究进展

Research Advances in Microcystin Biosynthesis Gene and Its Function

水体富营养化加剧,导致了蓝藻水华在世界范围内频发。蓝藻产生的微囊藻毒素是最常见的一种藻毒素,对人类和动物造成了很大的危害甚至导致死亡。微囊藻毒素经非核糖体合成途径由多肽合成酶合成。对微囊藻毒素的结构与性质、微囊藻毒素合成基因的功能及其生物合成、微囊藻毒素的分子生物学检测技术进行了评述,对未来的研究方向进行了展望。

The frequency and severity of bloom events continue to rise, most probably as a direct result of increased nutrient loading of water systems worldwide. Mierocystins （MCs） produced by cyanobacteria are the most commonly encountered cyanotoxin, which have been the cause of human and animal health hazards and even death. Microcystins are synthesized by peptide synthetases through nonribosomal pathways. The recent studies on the structure and property of MC, MC synthetase gene and its function, biosynthesis of microcystins, molecular biological technologies were reviewed, the future research directions are put forward.