巨细胞病毒感染对婴幼儿体质量影响及与病毒拷贝数相关性分析

Effect of cytomegalovirus infection on infant weight growth and correlation between the weight growth and copies number of the virus

目的 探讨人巨细胞病毒（HCMV）感染对婴幼儿体质量增长的影响,并分析患儿各年龄段体质量增长率与病毒拷贝数的相关性.方法 采用荧光定量聚合链反应（FQ-PCR）方法检测2012年10月至2013年10月收治的168例HCMV感染儿童尿液中HCMV-DNA载量,并采取回顾性调查研究的流行病学方法比较HCMV感染患儿的年龄别体质量与同年龄正常儿童的体质量,并对HCMV感染患儿体质量增长率与病毒拷贝数进行相关性分析.结果 168例患儿尿液标本HCMV-DNA均为阳性,年龄分布为1个月～3岁.3～6个月病毒感染患儿体质量增长率与病毒拷贝数呈负相关（r=-0.774,P＜0.01）.结论 巨细胞病毒感染患儿6个月前生长发育较同龄儿缓慢,6个月后逐渐加快至2岁与同龄儿基本接近;1岁前患儿体质量增长率较正常儿童有所下降;患儿体质量增长率与巨细胞病毒拷贝数呈负相关,3～6个月患儿负相关性尤为明显.

Objective To investigate the effect of cytomegalovirus（HCMV） infection on infant bodyquality growth,and analysis of the correlation between children of all ages body-quality growth rate and copy number of the virus.Methods One hundred and sixty-eight children with HCMV infection were enrolled in the current study who were hospitalized from Oct.2012 to Oct 2013 in the Affiliated Hospital of Xuzhou Medical College.Children＇s urine HCMV-DNA copy number was measured by TaqMan probe fluorescence quantitative PCR.The retrospective study was conducted to compare the HCMV infection in children with weight-for-age and normal children.The correlation between children with body-quality growth rate and copy number of the virus was analyzed.Results All 168 urine specimens were positive regarding HCMV-DNA.The age of all distribution was from 1 month to 3 years.There was a negative correlation between the increase body weigh and the copies of virus of children with 3-6 months （r =-0.774,P 〈 0.01）.Conclusion The growth and development of children with HCMV at age before 6 months were slower than Children with the same age.The growth of cytomegalovirus infection increase gradually speeding when they were over 6 months and it was approaching to that same age when they are 2 years old.The growth rate is lower than that of normal children when HCMV children were before 1 years old.The correlation of body-quality growth rate and the number of copies of the virus was negative,especially from 3 months to 6 months.