雪松松针正丁醇部位化学成分的研究

Chemical constituents in n-butanol extract from pine needles of Cedrus deodara

目的对雪松Cedrus deodara松针正丁醇部位的化学成分进行研究。方法利用硅胶柱及Sephadex LH-20凝胶色谱柱分离、纯化,并根据理化性质及波谱数据进行结构鉴定。结果从雪松松针正丁醇部位分离得到10个化合物,分别鉴定为1-(4′-羟基-3′-甲氧基苯基)-2-[4″-(3-丙醇基)-2″-甲氧基苯基]-1,3-丙二醇(1)、(7S,8R)-9,9′-二羟基-3,3′-二甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素-4-O-β-D-葡糖苷(2)、(7R,8R)-3′,9,9′-三羟基-3-甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素-4-O-α-L-鼠李糖苷(3)、(6R,9R)-6-羟基3-oxo-α-ionol-9-O-β-D-glucopyranoside(4)、(6R,9R)-3-oxo-α-ionol-9-O-β-D-glucopyranoside(5)、莽草酸正丁酯(6)、奎宁酸正丁酯(7)、(6S,9R)-6-hydroxy-3-oxo-α-ionol-9-O-β-D-glucopyranoside(8)、5-p-trans-coumaroylguinic acid(9)、(E)-1-O-对香豆酰基-α-D-吡喃葡萄糖苷(10)。结论化合物1～7为首次从该属植物中分离得到。

Objective To investigate the chemical constituents in the n-butanol extract of pine needles of Cedrus deodara. Methods Chemical constituents were separated and purified by silica gel and Sephadex LH-20 chromatography column. The structures were elucidated on the basis ofphysicochemical properties and spectral data （1H-NMR, 13C-NMR, and DEPT）. Results The compounds were identified as 1-（4＇-hydroxy-3＇-methoxyphenyl）-2-[4＂-（3-hydroxypropyl）-2＂-methoxyphenoxy]-l, 3-propanediol （1）, （7S, 8R）-9, 9＇-dihydroxy-3, 3＇-dimethoxy-7, 8-dihydro-benzofuran-l＇-propanol base neolignan-4-O-β-D-glucoside （2）, （7R, 8R）-3＇, 9, 9＇- trihydroxy-3-methoxy-7, 8-dihydro-benzofuran-l＇-propanol base neolignans-9-O-β-L-rhamnoside （3）, （6R, 9R）-6-hydroxy-3-oxo-a- ionol-9-O-β-D-glucopyranoside （4）, （6R, 9R）-3-oxo-ct-ionol-9-O-β-D-glucopyranoside （5）, shikimic acid butyl ester （6）, quinic acid butyl ester （7）, （6S, 9R）-6-hydroxy-3-oxo-a-ionol-9-O-β-D-glucopyranoside （8）, 5-p-trans-coumaroylguinic acid （9）, and （E）-1-O-β- coumaroyl-ct-D-glucopyranoside （10）. Conclusion Compounds 1--7 are isolated from C. Trew for the first time.