表没食子儿茶素没食子酸酯对心脑血管缺血再灌注损伤保护作用机制的研究进展

Research progress on neuroprotective mechanism of epigallocatechin-3-gallate against cardiovascular and cerebrovascular ischemia-reperfusion injury

表没食子儿茶素没食子酸酯(epigallocatechin-3-gallate,EGCG)是绿茶的主要成分之一。研究表明,EGCG具有抗氧化、预防癌症、抗炎、抗菌等作用。近年来,心脑血管疾病已成为当今世界影响人类健康最显著的疾病,而目前仅有少数神经保护药物能够用于治疗缺血性中风。很多基础研究证实,EGCG对于心脑血管缺血再灌注损伤具有独特的疗效,主要体现在调节氧化应激、抗细胞凋亡、抗炎、激活腺苷受体、降低血脑屏障的通透性及降低基质金属蛋白酶-9(MMP-9)表达等方面。针对EGCG对心脑血管缺血再灌注损伤保护作用机制进行综述,以期能为有效治疗心脑血管缺血性疾病药物的开发提供参考。

Epigallocatechin-3-gaUate （EGCG） is one of the major components in green tea. It has been studied that EGCG possesses anti-oxidative, anticancer, anti-inflammatory, and antibacterial effects. In recent years, cardiovascular and cerebrovascular diseases have been exerting the most significant impact on human health, however, only a few neuroprotective drugs can be used in the treatment of ischemic stroke. Many studies reveal that EGCG has unique therapeutic effect on cardiovascular and cerebrovascular ischemia-reperfusion injury. EGCG mainly exerts its protective effects by regulating oxidative stress, anti-apopsis, anti-inflammation, activation of adenosine receptors, lowering blood-brain barrier permeability, and reducing matrix metalloproteinase-9 expression. This review focuses on the mechanism of action of EGCG in the treatment of cardiovascular and cerebrovascular ischemia-reperfusion injury, in order to provide rationale or the development of effective drugs for ischemic cardiovascular and cerebrovascular diseases.