肺表面活性蛋白A和社区获得性肺炎预后的相关性研究

A Correlation Study of the Prognosis of Community Acquired Pneumonia and Pulmonary Surfactant Protein A

目的探讨肺表面活性蛋白A(SP-A)和社区获得性肺炎(CAP)预后的相关性。方法随机选取南方医科大学珠江医院2011年9月—2013年10月100例CAP患者,按病情CURB-65评估标准将患者分为轻度组、中度组和重度组;依照CAP危重评级的标准[7],将患者分为低危组、中危组、高危组、极高危组,组间比较临床预后指标(住院时间、机械通气和氧合指数)的差异。结果中度组与重度组患者的SP-A含量、氧合指数均显著低于轻度组(P<0.05),住院时间、机械通气时间均显著高于轻度组(P<0.05);中危组、高危组、极高危组患者的SP-A含量、氧合指数均显著低于低危组(P<0.05),住院时间、机械通气时间均显著高于低危组(P<0.05)。结论 SP-A是一种敏感、准确的生物特异性指标,在CAP病情程度和预后中具有重要的评估价值。

Objective To study the correlation between prognosis of community acquired pneumonia （ CAP） and pulmonary surfactant protein A （SP-A） . Methods A total of 100 CAP patients were randomly selected from Zhujiang Hospital of Southern Medical University during September 2011 and October 2013. The patients were divided into mild group, moderate group and severe group according to the CURB-65 evaluation criteria, and were divided into mild risk group, moderate risk group, high risk group and very high risk group according to critical rating standard. The differences of clinical prognostic indexes （ hospitalization time, mechanical ventilation and oxygenation index） were compared among the groups according to the same standard. Results The levels of SP-A content and oxygenation index in moderate and severe groups were significantly lower than that in mild group （P〈0. 05）, and hospitalization and mechanical ventilation times were significantly longer than that in mild group （P〈0. 05）;the levels of SP-A content and oxygenation index in medium risk, high risk and very high risk groups were significantly lower than that in low risk group （P〈0. 05）, while the hospitalization and mechanical ventilation times were significantly longer than that in low risk group （ P 〈0. 05 ） . Conclusion SP-A is a sensitive and accurate biological specificity index, and it has important assessment value in dis-ease severity degree and prognosis of community acquired pneumonia.