联合抗栓治疗对心肌梗死患者血清IL-6、TNF-α、CPR水平的影响

Impact of combined antithrombotic therapy on serum IL-6, TNF-α, CPR levels of patients with myocardial infarction

目的探讨联合抗栓治疗对心肌梗死患者血清IL-6、TNF-α、CPR水平的影响。方法选取2011年8月—2013年8月我院收治的100例心肌梗死患者,依据随机数字表法将这些患者分为两组,即观察组(50例)和对照组(50例)。给予对照组患者低分子肝素+阿司匹林治疗,给予观察组患者低分子肝素+阿司匹林+左卡尼汀治疗。结果观察组患者治疗的总有效率90.0%(45/50)明显比对照组72.0%(36/50)高(P<0.05),血清IL-6、TNF-α水平均明显比对照组低(P<0.05),CPR水平明显比对照组高(P<0.05)。结论联合抗栓治疗能够有效改善心肌梗死患者的血清IL-6、TNF-α、CPR等炎性指标。

Objective To investigate the impact of combined antithrombotic therapy on serum IL-6, TNF-α, CPR levels of patients with myocardial infarction. Methods 100 cases of myocardial infarction patients in our hospital from August 2011 to August 2013 were selected, these patients were divided into two groups according to the random number table, namely the observation group（50cases） and control group（50 cases）. The control group were given low molecular weight heparin ＋ aspirin therapy, while the observation group were given low molecular weight heparin ＋ aspirin ＋ L-carnitine therapy. Results The total effective treatment of the observation group 90.0%（45/50） was significantly higher than the control group72.0%（36/50）（P〈0.05）, The serum IL-6, TNF-αlevels of the observation group were significantly lower（P〈0.05）, the CPR level was significantly higher than the control group（P〈0.05）. Conclusion The combined antithrombotic therapy can improve the levels of serum IL-6, TNF-α, CPR and other inflammatory markers of patients with myocardial infarction effectively.