影响新疆维吾尔族人群胰岛素抵抗的相关因素分析

Analysis of related factors influencing Xinjiang Uygur insulin resistance

目的分析影响新疆维吾尔族人群胰岛素抵抗的相关因素。方法对第三次全国糖尿病流行病学调查中新疆维吾尔族人群的资料进行分析,采用稳态模式评估法的胰岛素抵抗(IR)指数(HOMA-IR)作为IR的评价指标,利用多元线性回归,了解相关因素对其的影响。结果在多元线性回归分析中,未纳入BMI和腰围的情况下,甘油三酯、总胆固醇与HOMA-IR呈正相关(P=0.016,P=0.038);纳入腰围后,腰围与HOMA-IR呈正相关(P=0.000);同时纳入BMI、腰围,BMI、甘油三酯与HOMA-IR呈正相关(P=0.000,P=0.045)。结论在不考虑人体学指标的情况下,单纯从生化指标甘油三酯和总胆固醇就可以初步了解维吾尔族人群IR的情况;"腰围"可以独立的判断IR程度;但当考虑到BMI的因素时,腹围的预测作用就消失了,而被BMI和甘油三酯所取代;在维吾尔族人群中,BMI可能较腹围具有更好的预测作用。

Objective To analyze related factors influencing Xinjiang Uygur insulin resistance. Methods We employed the third national diabetic epidemiological survey--data of Xinjiang Uygur population for analysis, and took HOMA-IR as index of insulin resistance（IR）, by using multiple regression analysis, we studied influence of related factors on HOMA-IR. Results In multiple regression analysis, with exclusion of BMI and waist circumference（WC）, triglyceride（TG） and total cholesterol（TC） was positively correlated with HOMA-IR（P=0.016, P=0.038）;then with WC in, WC was positively correlated with HOMA-IR（P=0.000）;with both BMI and WC in, BMI and Triglyceride was positively correlated with HOMA-IR（P=0.000, P=0.045）. Conclusion Without consideration of BMI and WC, TG and TC could be used as a preliminary understanding of Uygur individual’s IR;and WC could predict IR independently;When BMI was included, predictive role of WC was disappeared, and BMI and TG took its place for instead;BMI might be a stronger predictor than WC in Uygur population.