禽TCR谱系分析的研究进展

Research Progress of Avian TCR Repertoire Analysis

禽T细胞通过TCR将外部信号转化为内部信号,刺激T细胞增殖分化并发挥效应功能。对TCR谱系进行分析,可以充分展示机体的TCR克隆状况,从而对机体的免疫功能进行全面评估。TCR谱系分析技术已广泛应用于病原体感染、肿瘤、自身免疫性疾病等领域。利于TCR谱系分析技术研究禽类动物在病原体感染和肿瘤疾病发生中TCR克隆的变化情况,能够为病原体的生物学特性以及相关疾病的诊断与防控提供更多的研究资源。

Avian T cell can convert the extemal signal into internal signal via TCR, which can stimulate T cell proliferation and differentiation and play an important role in immune function. TCR clones of the body can be fully shown and evaluate the immune functions comprehensively by TCR repertoire analysis. The technologies of TCR repertoire analysis have been extensively applied to the fields of pathogen infection, tumor, autoimmune disease, and so on. More useful research resources about the biological characteristics of pathogens, diagnosing, preventing and controlling the relevant diseases can be provided by exploring the changes of TCR clones in avian pathogen infection and tumor diseases with using the technologies of TCR repertoire analysis.