难治性抑郁症患者MECT治疗前后血清VEGF水平的变化

Alteration of serum VEGF level after MECT treatment in patients with treatment resistant depression

目的探讨难治性抑郁症(TRD)患者血清血管内皮生长因子(VEGF)水平在改良电抽搐治疗(MECT)治疗前后的变化情况。方法采用酶联免疫吸附法检测26例TRD患者MECT治疗前后及27例正常对照者的血清VEGF浓度;采用汉密尔顿抑郁量表17项(HAMD-17)评估TRD患者的临床症状。组间血清VEGF浓度比较采用Wilcoxon符号秩和检验,治疗前后血清VEGF浓度变化与HAMD总评分的相关性分析使用Speaman秩相关。结果 TRD患者MECT治疗后24例(92.3%)达到治疗有效标准。TRD组MECT治疗前血清VEGF水平与对照组差异无统计学意义(P>0.05);MECT治疗后血清VEGF水平有升高趋势,但差异无统计学意义(P>0.05)。治疗前后血清VEGF浓度与HAMD总评分变化的相关性有统计学意义(r=-0.663,P<0.01)。结论血清VEGF水平变化可能对临床疗效的评估有一定参考价值。

Objective To investigate the changes of serum VEGF after MECT treatment in TRD patients. Methods Twenty - six TRD patients who completed MECT treatment and twenty - seven healthy volunteers were enrolled in current study. Serum VEGF levels were measured by ELISA. Clinical symptoms were evaluated with HAMD - 17. Wilcoxon Rank Sum Test was applied on the differences between TRD patients and healthy volunteers of serum VEGF concentration, as well as the differences before and after MECT I! treatment in TRD. Spearmen correlation was applied to analyze the association between changes of serum VEGF ＇concentration and total HAMD scores. Results Of 24 （ 92.3% ） patients had symptom relieves after MECT treatment. In comparison to lore - treatment, TRD patients serum VEGF level was not significantly different from healthy volunteers （ P 〉 0.05 ）. TRD patients Serum VEGF level after MECT treatment exhibited tendency of increase, which was not significant（P 〉 0.05 ）. The relationship between the changes of serum VEGF level and total HAMD scores were significant （ r = - 0. 663, P 〈 0.01 ）. Conclusion The result indicated that serum VEGF level might be a useful index for clinical evaluation in antidepressant treatment.