42例肺部真菌感染患者抗菌药物预防给药的临床效果

Effect observation of antibacterial drugs prophylaxis on 42 patients with pulmonary fungal infection

目的回顾性分析42例肺部真菌感染患者特征和预防性用药的作用。方法选择四平市中心医院重症监护室(ICU)2012年6月至2013年6月肺部疾病重症患者42例作为研究对象。预防组22例患者在真菌感染不良症状出现前预防性给药;对照组20例患者在发现真菌感染,确诊感染菌种后再对症给予抗菌药物。对比两组患者临床治疗效果和真菌感染特点。结果预防组肺部真菌感染发生率为54.5%,远远低于对照组的95.0%,差异具有统计学意义(P<0.01)。在31例ICU受试患者中,肺部真菌感染的病原菌以白假丝酵母菌检出比例最高,为83.9%,明显高于光滑假丝酵母菌的9.7%和近平滑念珠菌的6.5%。结论预防性给药能提高ICU患者肺部真菌感染的治疗效果,但需合理用药,根据疾病特征选择用药类型。

Objective To analyze retrospectively the effect of of antibacterial drugs prophylaxis on 42 patients with pulmonary fungal infection .Methods Forty two patients with pulmonary fungal infection from June in 2012 to June in 2013 were divided into study group（22 patients）and control group（20 patients） randomly .Twenty two pa-tients in the study group were gave antibiotics prophylaxis before the symptoms of the fungal infection appeared ,20 patients in the control group were only treated by antibiotics after the symptoms of fungal infection appeared .Charac-teristics of infection and the treatment effect in the two groups were compared .Results The incidence of pulmonary fungal infection in the study goup was 54 .5% ,which was significant lower than 95% of the control group （P〈0 .01） .In 31 ICU patients ,Candida albicans was the highest proportion of pulmonary fungal infection ,with the rate as 83 .9% ,which was significant higher than that of Candida glabrata （9 .7% ） and Candida parapsilosis （6 .5% ） .Con-clusion Adopting antibiotics prophylaxis on the patients with pulmonary fungal infection could improve the effect , but should pay attention to rational drug using and disease characteristics .