血清胱抑素C联合尿微量清蛋白检测在诊断高血压早期肾功能损害中的价值

Clinical application of combined detection of serum cystatin C and micro-albuminuria in early renal function injury patients caused by hypertension

目的分析血清胱抑素C(Cys C)联合尿微量清蛋白(mALB)检测在高血压早期肾功能损害中的诊断价值。方法选择2012年1月至2013年12月南京市中西医结合医院320例患者为研究对象,其中高血压组130例,肾功能损害组90例,健康对照组100例。检测每组mALB、肌酐(Scr)、尿素氮(BUN)、Cys C水平,并比较每组Scr、BUN及mALB联合Cys C检测对早期肾功能损害的检出率。结果高血压组mALB、Cys C水平,肾功能损害组mALB、Scr、BUN、Cys C水平均明显高于健康对照组,差异均有统计学意义(P<0.05)。高血压组Scr、BUN对早期肾功能损害检出率为13.8%、14.6%,均明显低于mALB联合Cys C(32.3%),差异均有统计学意(P<0.05);肾功能损害组Scr、BUN对早期肾功能损害检出率均为53.3%,mALB联合Cys C检出率则为100.0%,差异均有统计学意(P<0.05)。结论 Cys C联合mALB检测可显著提高高血压早期肾功能损害的检出率,值得临床推广应用。

Objective To analyze the clinical effect of serum cystatin C （Cys C）and micro-albuminuria（mALB） in early renal function injury patients caused by hypertension .Methods One hundred and thirty patients in hyperten-sion group ,90 patients in renal function injury group ,and 100 healthy people in health group were recruited in this study .The level of mALB ,Scr ,BUN ,Cys C were detected .The detection rate of early renal function injury in the three groups were compared .Results The level of mALB ,Cys C in the hypertension group ,the level of mALB ,Scr , BUN ,Cys C in the renal function injury group were significant higher than those indicators in the control group .The detection rates of Scr ,BUN for early renal function injury in the hypertension group were 13 .8% ,14 .6% respective-ly ,which were significantly lower than the rate 32 .3% of united detection mALB and Cys C .In the renal function in-jury group ,the detection rate of Scr ,BUN for the early renal function injury were 53 .3% ,53 .3% respectively ,while the rate of the united mALB and Cys C was 100 .0% ,the differences were statistically significant （P〈0 .05） .Conclu-sion United detection of mALB and Cys C could significantly improve the detection rate for early renal function inju-ry .