恶性疟原虫蛋白输出机制的研究进展

Advances in the study of the mechanism of protein export by Plasmodium falciparum

疟疾是由疟原虫引起的虫媒传染病。近些年,由于疟原虫抗药性的产生和迅速扩散,给疟疾治疗带来严重困难,因此,研制安全有效的疫苗是预防疟疾感染,控制疟疾流行的主要手段之一。疟原虫致病机制研究已经成为研制抗疟疫苗及疾病防控的一项重点,由于多种疟原虫输出型蛋白能够运输到宿主细胞表面进行信息传递并可使虫体逃避宿主的免疫反应,因此研究虫体输出型蛋白转运机制对疟原虫致病机制研究有着至关重要的意义。本文概述了疟原虫蛋白输出的机制,以及NPPs、TVN、MCs、Knobs和PTEX等5种疟原虫重要的蛋白输出结构的研究进展。

Malaria is an infectious disease caused by the parasite Plasmodium.Over the past few years,the control of malaria has been seriously hampered by the parasite＇s drug resistance and its quick spread.Therefore,a safe and effective malaria vaccine is one of the most important ways to prevent malaria infection.Studying the pathogenesis of malaria is key to developing an anti-malaria vaccine.Study of the parasite＇s mechanism of protein transport is crucial to the study of the parasite＇s mechanism of pathogenesis since it exports a number of proteins that are transported to the surface of host cells where they communicate with the parasite and allow it to evade the host＇s immune response,.This review summarizes the mechanism of protein translocation and advances in the study of five components-NPPs,TVN,MCs,Knobs,and PTEX-that are key to the parasite＇s protein export.