4Boukamp P, Mirancea N. Telomeres rather than telomerase a key target for anti-cancer therapy? Exp Dermatol. 2007;16(1 ):71-79.
5Mc-Clintock B. The Production of Homozygous Deficierlt tissues with Mutant Characteristics by Means of the Aberrant Mitotic Behavior of Ring-Shaped Chromosomes. Genetics. 1938;23(4):315-376.
6Hao LY, Armanios M, Strong MA, et al. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell. 2005;123(6):1121-1131.
7Blackburn EH. Telomere states and cell fates. Nature. 2000;408 (6808):53-56.
8Shav JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis. 2005;26(5):867-874
9Greider CW. Telomerase RNA levels limit the telomere length equilibrium. Cold Spring Harb Symp Quant Biol. 2006;71:225-229.
10Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006;12(10):7-12.
5Chen W,Zheng R,Zhang S,et al. Annual report on status of cancer in China,2010 [ J]. Chung-kuo yen cheng yen chiu, 2014, 26 ( 1 ) : 48 - 58.
6Ornish D, Lin J, Chan JM,et al. Effect of comprehensive lifestyle chan- ges on telomerase activity and telomere length in men with biopsy-prov- en low-risk prostate cancer: 5-year fellow-up of a descriptive pilot study [J]. Lancet Oncol,2013,14(11) : 1112 -1120.
7Donate LE, Blasco MA. Telomeres in cancer and ageing [ J ]. Philos Trans R Soc Lond, B, Biol Sci,2011,366 ( 156 l ) : 76 - 84.
8Zheng YL, Ambrosone C, Byrne C, et al. Telomere length in blood cells and breast cancer risk: investigations in two case-control studies [ J ]. Breast Cancer Res Treat, 2010,120 ( 3 ) : 769 - 775.
9Arai Y, Martin-Ruiz CM,Takayama M,et at. Inflammation, But Not Te- lomere Length,Predicts Successful Ageing at Extreme Old Age: A Lon- gitudinal Study of Semi-supercentenarians [ J ]. EBioMedicine, 2015,2 (10) : 1549-1558.
