高原短期暴露人群返回低海拔地区后脱适应期血清皮质醇水平的变化

Deadaptation change of serum cortisol when people return to low altitude regions after short-term exposure to high altitude populations

目的了解高原短期暴露人群返回低海拔地区后脱适应期皮质醇水平的变化。方法对参加高原(海拔3 700m以上)军事任务116天后返回平原的官兵在返回后的第2天、第15天和第30天分别采集清晨空腹静脉血,采用放射免疫法分析血清皮质醇浓度。未上高原的140例官兵作为对照,进行同样的检测。结果高原短期暴露人群,血清皮质醇呈先升高后下降趋势。官兵返回平原第2、15天时的皮质醇水平明显高于对照人群和返回平原后第30天的水平(P<0.05),且第15天时明显高于第2天(P<0.05)。官兵返回平原后第30天时与对照人群比较,差异无统计学意义(P>0.05)。结论高原短期暴露人群返回平原初期皮质醇水平变化明显,且与高原脱适应症状相关。

Objective To investigate the change of serum cortisol concentration during the adjustment period of people who had returned to low-altitude areas with short-term exposure to high altitude .Methods Serum cortisol concentrations were determined by radioimmunoassay .Fasting blood samples were collected on the 2nd ,15th day and 30th day from soldiers who had returned from high altitude area where they spent 116 days to finish plateau military mission（observation group） .In addition to that ,140 soldiers without that mission were recruited as control group .Results Serum cortisol concentration of people exposed to high altitude in-creased at first and then decreased .After coming back from high altitude area ,on the 2nd day and 15th day ,serum cortisol concen-trations were significantly higher in observation group than control group and observation group on the 30th day（P〈0 .05） .Serum cortisol concentrations on the 15th day were statistically higher than that on the 2nd day（P〈0 .05） .There was no significant differ-ence between the concentrations on the 30th day and that of control group（P〉0 .05） .Conclusion Short-term exposure to high alti-tude leads to significant change of serum cortisol concentrations after returning to the low altitude areas ,and the change associated with the high altitude deadaptation .