血清VEGF CEA CA19-9和SF水平变化在晚期胃癌患者化疗疗效评估中的价值

Values of serum VEGF,CEA,CA19-9 and SF for predicting the efficacy to chemotherapy in advanced gastric cancer

目的探讨检测晚期胃癌患者血清血管内皮生长因子(VEGF)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)和铁蛋白(SF)水平变化在化疗疗效评估中的价值。方法测定85例晚期胃癌患者化疗前、化疗1周期后血清VEGF、CEA、CA19-9和SF的水平;并在化疗2周期后进行疗效评价。结果化疗有效组血清VEGF、CEA、CA19-9和SF水平均较化疗前明显下降(P<0.05);进展组血清VEGF、CEA水平均较化疗前明显上升(P<0.05);稳定组血清VEGF、CEA、CA19-9、SF及进展组血清CA19-9、SF水平均较治疗前无明显变化(P>0.05);多重回归分析显示,血清CEA、VEGF、CA19-9水平变化与化疗疗效相关,具有统计学意义,而血清SF与化疗疗效相关性无统计学意义(t=1.58,P=0.119)。结论血清CEA、VEGF、CA19-9水平变化与胃癌化疗疗效相关,其检测有助于预测化疗效果。

Objective To investigate the values of serum vascular endothelial growth factor （VEGF） ,carcinoembryonic antigen （CEA） ,carbohydrate antigen 19-9 （CA19-9） and ferritin （SF） determination in assessing the efficacy of chemotherapy in patients with advanced gastric cancer .Methods Wedetermined the concentrations of serum VEGF ,CEA ,CA19-9 and SF for 85 patients with advanced gastric cancer ,before and after 1 cycles of chemotherapy and evaluated the the effect of chemotherapy after 2 cycle of chemotherapy .Results In effective group ,serum concentrations of VEGF ,CEA ,CA19-9 and SF significantly decreased after chem-otherapy cycle（P〈 0 .05） ,serum VEGF and CEA concentrations significantly increased in progress group （P〈 0 .05） ,serum VEGF ,CEA ,CA19-9 and SF concentrations in stable group and serum CA19-9 and SF concentrations in progress group did not change significantly（P〉 0 .05） ,compared with those before chemotherapy cycle .Multiple regression analysis showed that serum CEA ,VEGF ,CA19-9 concentration changes correlated with chemotherapy efficiency ,while serum SF didn′t（t=1 .58 ,P=0 .119） . Conclusion Serum CEA ,VEGF ,CA19-9 concentration changes associated with gastric cancer chemotherapy efficiency ,which help predict the efficiency of chemotherapy .