铁调素检测在缺铁性贫血与慢性贫血鉴别诊断中的价值

Hepcidin measurement in the differential diagnosis of iron deficiency anemia and anemia of chronic disease

目的探讨铁调素(hepcidin)对缺铁性贫血(IDA)及慢性贫血(ACD)的鉴别诊断价值。方法采用ELISA法检测78例体检健康人群(对照组)、40例ACD患者(ACD组)及49例IDA患者(IDA组)的血清铁调素水平。亚铁嗪比色法检测血清铁、总铁结合力水平(TIBC)。结果 IDA组血清铁调素水平低于体检组(P<0.05),ACD组铁调素水平高于对照组(P<0.05)。铁调素、血清铁、TIBC用于ACD与IDA患者鉴别诊断的ROC曲线下面积分别为0.97、0.66、0.85。结论铁调素为鉴别诊断IDA和ACD简单易行的方法,其诊断准确度优于血清铁和TIBC。

Objective To explore the value of hepcidin measurement in differential diagnosis of iron deficiency anemia（IDA） and anemia of chronic diseases（ACD） .Methods Serum hepcidin was measured by using ELISA .Serum iron（SI） and total iron binding capacity（TIBC） were determined by using Ferro zine colorimetric method .Results Hepcidin expression increased in ACD group （P〈0 .05） ,but decreased in IDA group（P〈0 .05） .The area under the curve of ROC for hepcidin ,SI and TIBC were 0 .97 ,0 .66 and 0 .85 respectively .Conclusion Hepcidin is a simple and safe indicator in differential diagnosis of IDA and ACD ,and its diagnos-tic accuracy is better than SI and TIBC .