广州番禺地区健康儿童血清ALT和TB检测参考范围的建立

Reference range establishment for healthy children's ALT and TB test in Panyu district of Guangzhou

目的：调查番禺地区儿童血清丙氨酸氨基转移酶（ALT ）和总胆红素（TB）水平，建立不同性别和不同年龄健康儿童血清ALT和TB的参考范围。方法随机抽取4065例儿童进行体检，并对其进行血清 ALT 和 TB检测，剔除离群数据后进行统计分析。结果筛除离群数据后，共4000例受试者入选，男2241例、女1759例，年龄2～＜9岁。根据统计结果，分性别、年龄建立参考范围。男性ALT的参考范围为2～＜3岁：5．0～36．0U/L，3～＜4岁：7．0～21．0U/L，4～＜8岁：6．0～21．0U/L，8～＜9岁：5．0～24．0 U/L ；男性TB的参考范围为2～＜3岁：3～12μmol/L ，3～＜7岁：4～15μmol/L、7～＜8岁：4～16μmol/L和8～＜9岁：7～12μmol/L。女性ALT的参考范围为2～＜3岁：6．0～30．0U/L，3～＜4岁：7．0～22．0U/L，4～＜9岁：6．0～19．0 U/L ；女性TB的参考范围为2～＜3岁：3．0～12．0μmol/L ，3～＜4岁：3．0～13．0μmol/L ，4～＜9岁：4．0～16．0μmol/L。结论初步建立了番禺区健康儿童血清ALT和TB检测值的参考范围。

Objective Toinvestigateserumalanineaminotransferase（ALT）andtotalbilirubin（TB）concentrationsofchildrenin Panyu district of Guangzhou ,and establish the reference ranges for ALT and TB tests for healthy children of different gender and different age .Methods 4 065 children were chosen randomly ,and their serum ALT and TB were determined .After excluding the outliers ,the results were analyzed statistically .Results After excluding outliers ,a total of 4 000 children were enrolled in the stud-y ,including 2 241 males ,1 759 females ,aged 2- 〈9 years old .According to statistical analysis ,reference ranges were established . For male the ALT reference ranges were as follows ,2- 〈3 years old ：5 .0-36 .0 U/L ,3- 〈4 years old ：7 .0-21 .0 U/L ,4- 〈8 years old ：6 .0-21 .0 U/L ,8- 〈9 years old ：5 .0-24 .0 U/L ;TB reference ranges of male were as follows ,2- 〈3 years old ：3-12μmol/L ,3- 〈7 years old ：4-15 μmol/L ,7- 〈8 years old ：4-16 μmol/L ,8- 〈9 years old ：7-12 μmol/L .ALT reference range of female were as follows ,2- 〈3 years old ：6 .0-30 .0 U/L ,3- 〈4 years old：7 .0-22 .0 U/L ,4- 〈9 years old ：6 .0-19 .0 U/L ;female TB reference range ,2- 〈3 years old ：3 .0-12 .0 μmol/L ,3- 〈4 years old ：3 .0-13 .0 μmol/L ,4- 〈9 years old：4 .0-16 . 0 μmol/L .Conclusion Established the reference ranges of ALT and TB test for healthy children in Panyu district .