高血压及糖尿病患者颈动脉硬化与高同型半胱氨酸的关系

Relationship between cayotid atherosclerosis and homocysteine in elderly people with hypeytension and type 2 diabetes mellitus

目的探讨老年高血压、2型糖尿病患者颈动脉粥样硬化程度与血高同型半胱氨酸(Hcy)水平的相关性。方法选择医院老年患者120例,按其原发病分为单纯高血压病组(HBP组)、单纯糖尿病组(DM组)、高血压合并2型糖尿病组(HBP+DM组)各40例,另选择年龄、性别相匹配的无高血压、糖尿病患者40例为对照组,测定4组Hcy、动脉壁内膜—中膜厚度(IMT),计算斑块检出率并进行比较。结果 HBP组、DM组、HBP+DM组Hcy水平、IMT、斑块检出率较对照组明显增高,差异有统计学意义(P<0.05)。结论 Hcy升高水平与颈动脉硬化程度相一致。

Objective To investigate the relativity between carotid atherosclerosis and homocysteine level in elderly patients with hypertension or type 2 diabetes mellitus. Methods 120 cases of elderly patients,according to their primary diseases, were divided into simple hypertension group （HBP group）, diabetes mellitus group （DM group）, hypertension and type 2 diabetes mellitus group （HBP ＋ DM group） , each of 40 cases,40 patients without hypertension and diabetes patients were selected as control group. Detected and＇compared the Hcy level,the carotid artery intimal -medial thickness,and the detection rate of carotid plaques. Results In HBP group, DM group and HBP ＋ DM group,the Hcy level,the carotid artery intimat-medial thickness, and the detection rate of carotid plaques were significantly higher than the control group. The difference was statistically significant （P 〈 0.05）. Conclusion The increase of Hcy is consistent with the degree of carotid atherosclerosis.