摘要
目的:观察戊己丸传统汤剂、复方及配方颗粒剂镇痛、止泻和抗急性胃溃疡作用,比较不同剂型的药效差异.方法:将小鼠或大鼠分为对照组、阳性药组和戊己丸传统汤剂、复方及配方颗粒剂高、中、低剂量组(小鼠4.0,2.0,1.0 g·kg-1;大鼠2.8,1.4,0.7 g·kg-1),ig给药3-8d,制作乙酸致痛、番泻叶致泻及无水乙醇致大鼠急性胃溃疡模型,观察戊己丸汤剂、复方及配方颗粒剂的镇痛、止泻和抗急性胃溃疡作用.结果:与对照组比较,戊己丸汤剂、复方及配方颗粒4.0,2.0,1.0 g·kg-1能明显抑制乙酸引起的小鼠扭体反应;减少番泻叶引起的小鼠腹泻次数;其2.8,1.4,0.7 g·kg-1显著减轻无水乙醇导致的大鼠急性胃黏膜损伤.结论:戊己丸传统汤剂、复方及配方颗粒剂均有较好的止痛、止泻和抗急性胃溃疡作用,药效无明显差异.
Objective:To investigate the effects of Wuji Wan decoction,compound and recipe granules on analgesic,anti-diarrheal and antagonism acute gastric ulcer functions.Method:The animals were divided into control group,positive control group,high,middle,low dose groups of Wuji Wan decoction,compound and recipe granules (mice:4.0,2.0,1.0 g ·kg-1 ; rats:2.8,1.4,0.7 g ·kg-1),3-8 days after administration,analgesic,anti-diarrheal and acute gastric ulcer were observed with acetic acid writhing test,the diarrheal model was induced by senna and the model of acute gastric ulcer was induced by ethanol.Result:Compared with the control group,high,middle and low dose (4.0,2.0,1.0 g·kg-1) of Wuji Wan decoction,compound and recipe granules reduced the writhing times,decreased frequency of diarrhe,obviously reduced gastric mucosal injury in rats.Conclusion:Wuji Wan decoction,compound and recipe granules can decoction,compound and recipe granules show obvious analgesic,antidiarrheal and antagonism,acute gastric ulcer effects.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第21期158-161,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
贵阳市科技局项目:现代药业计划筑科合同【2012204】44号
关键词
戊己丸
不同剂型
镇痛
止泻
抗胃溃疡
Wuji pills
different dosage form
analgesic
anti-dianrrheal
anti-gastric ulcer