戊己丸3种剂型的镇痛、止泻及抗急性胃溃疡作用比较

Comparative Study of Analgesic,Anti-dianrrheal and Antagonism Acute Gastric Ulcer Effects of Wuji Wan Decoction,Compound and Recipe Granules

目的：观察戊己丸传统汤剂、复方及配方颗粒剂镇痛、止泻和抗急性胃溃疡作用,比较不同剂型的药效差异.方法：将小鼠或大鼠分为对照组、阳性药组和戊己丸传统汤剂、复方及配方颗粒剂高、中、低剂量组（小鼠4.0,2.0,1.0 g·kg-1;大鼠2.8,1.4,0.7 g·kg-1）,ig给药3-8d,制作乙酸致痛、番泻叶致泻及无水乙醇致大鼠急性胃溃疡模型,观察戊己丸汤剂、复方及配方颗粒剂的镇痛、止泻和抗急性胃溃疡作用.结果：与对照组比较,戊己丸汤剂、复方及配方颗粒4.0,2.0,1.0 g·kg-1能明显抑制乙酸引起的小鼠扭体反应;减少番泻叶引起的小鼠腹泻次数;其2.8,1.4,0.7 g·kg-1显著减轻无水乙醇导致的大鼠急性胃黏膜损伤.结论：戊己丸传统汤剂、复方及配方颗粒剂均有较好的止痛、止泻和抗急性胃溃疡作用,药效无明显差异.

Objective：To investigate the effects of Wuji Wan decoction,compound and recipe granules on analgesic,anti-diarrheal and antagonism acute gastric ulcer functions.Method：The animals were divided into control group,positive control group,high,middle,low dose groups of Wuji Wan decoction,compound and recipe granules （mice：4.0,2.0,1.0 g ·kg-1 ; rats：2.8,1.4,0.7 g ·kg-1）,3-8 days after administration,analgesic,anti-diarrheal and acute gastric ulcer were observed with acetic acid writhing test,the diarrheal model was induced by senna and the model of acute gastric ulcer was induced by ethanol.Result：Compared with the control group,high,middle and low dose （4.0,2.0,1.0 g·kg-1） of Wuji Wan decoction,compound and recipe granules reduced the writhing times,decreased frequency of diarrhe,obviously reduced gastric mucosal injury in rats.Conclusion：Wuji Wan decoction,compound and recipe granules can decoction,compound and recipe granules show obvious analgesic,antidiarrheal and antagonism,acute gastric ulcer effects.