单纯性肥胖症儿童血清内脂素、促酰化蛋白水平测定及其临床意义

Changes of visfatin, acylation stimulated protein level in simple obese children and their clinical significances

目的 探讨血清内脂素（visfatin）和促酰化蛋白（ASP）与单纯性肥胖症儿童发病的关系及其对肥胖症防治的意义.方法 研究对象共86例,男57例,女29例;年龄7～15岁.其中单纯性肥胖儿童40例;超重儿童22例;健康对照儿童24例.采用酶联免疫吸附法检测各组儿童血清visfatin、ASP水平.结果 1.肥胖组血清visfatin与健康对照组和超重组相比,分别增加了49.80％（P＜0.05）、35.88％ （P ＜0.05）.肥胖组血清ASP与健康对照组和超重组相比,分别增加了7.34％ （P ＜0.01）和5.57％（P＜0.05）.超重组和健康对照组血清visfatin及ASP比较差异均无统计学意义.2.肥胖组体质量指数（BMI）、总胆固醇、三酰甘油、低密度脂蛋白、空腹血糖、空腹胰岛素、胰岛素抵抗指数均高于健康对照组,差异均有统计学意义（P均＜0.05）;肥胖组高密度脂蛋白和胰岛素敏感指数明显低于健康对照组,差异均有统计学意义（P均＜0.05）;肥胖组BMI、空腹胰岛素、胰岛素抵抗指数均高于超重组,差异均有统计学意义（P均＜0.01）.3.相关性分析：血清visfatin与BMI、三酰甘油均呈正相关（r =0.218,P＜0.05;r =0.500,P＜0.01）.血清ASP与BMI、总胆固醇和三酰甘油均呈正相关（r=0.268,P＜0.05;r =0.250,P＜0.05;r =0.427,P＜0.01）.结论 Visfatin和ASP与肥胖关系密切,均参与肥胖儿童体内脂质代谢紊乱的发生.检测血清visfatin和ASP水平将有助于判断儿童肥胖症的发展趋势,有助于评价肥胖儿童未来发生糖尿病、心血管疾病的危险程度.

Objective To explore the relationship between visfatin,acylation stimulated protein （ASP） and the incidence of childhood obesity and the significance of them in diagnoses and therapy of children＇s obesity.Methods Eighty-six children（57 boys and 29 girls）including 40 obese children,22 overweight children and 24 healthy control children were recruited with ages ranged 7-15 years.Serum visfatin and ASP levels were determined by enzyme linked immunosorbent assay（ELISA）.Results 1.Compared with healthy and overweight children,serum visfatin level was significantly higher in obese children（P 〈 0.05） ;Compared with healthy children and overweight children,serum ASP levels were significantly higher in obese children （P 〈 0.01,0.05）.There were no differences of serum visfatin and ASP levels between healthy and overweight children.2.The body mass index （BMI）,total cholesterol （TC）,triglycerides （TG）,low density lipoprotein-cholesterol （LDL-C）,fasting plasma glucose （FPG）,fasting insulin （FINS）,insulin resistance index of the obese children were higher than those of the healthy children（all P 〈0.05） ;the high density lipoprotein-cholesterol（HDL-C） and insulin sensitivity index of the obese children were lower than those of the healthy group （all P 〈 0.05）.The BMI,FINS,insulin resistance index of the obese children were higher than those of the overweight children （P 〈 0.01）.3.Correlation analysis：serum visfatin,BMI and TG were positively correlated （r =0.218,P 〈 0.05 ; r =0.500,P 〈 0.01,respectively）.ASP and BMI,TC,TG were positively correlated （r =0.268,P 〈 0.05 ; r=0.250,P〈0.05;r=0.427,P〈0.01,respectively）.Conclusions In simple obesity children,there was a significant change in serum visfatin and ASP,and visfatin and ASP were involved in the disorder of lipids metabolism in obese children.Serum visfatin and ASP levels can be used as a new indicator to evaluate the risk of childhood obesity trends and future evaluation of diabetes and cardiovascular diseases.