银杏达莫与洛伐他汀联用对急性脑梗死患者的疗效及治疗后病残程度与脂质水平的相关性分析

Curative effect of Yinxingdamo and lovastatin on acute cerebral infarction and correlation of disabled degree after treatment with lipid levels

目的 研究银杏达莫（YXDM）与洛伐他汀（LOV）联用对急性脑梗死（ACI）患者的疗效及治疗后病残程度与脂质水平的相关性.方法 选择入院就诊的122例ACI患者作为观察对象.随机分两组,对照组只给予YXDM治疗,观察组给予YXDM ＋LOV治疗.对比两组患者全血黏度和血浆黏度,以及总胆固醇（TC）和三酰甘油（TG）水平,高密度脂蛋白胆固醇（HDL-C）及低密度脂蛋白胆固醇（LDL-C）等指标水平.对比两组疗效,并分析治疗后病残程度与脂质水平的相关性.结果 两组治疗后全血、血浆黏度均明显下降,且观察组全血黏度下降程度大于对照组;观察组治疗后TC、TG以及LDL-C水平均明显低于治疗前以及对照组在治疗后的水平,HDL-C水平高于治疗前以及对照组在治疗后的水平;观察组的总有效率显著高于对照组;差异均有统计学意义（均P＜0.05）.根据Spearman法分析后发现,患者治疗后的病残程度越高,TC、TG及LDL-C水平越高,均呈正相关（r=0.857,0.832,0.794;P =0.004,0.012,0.003）,但HDL-C水平越低,呈负相关（r=-0.842,P=0.010）结论 YXDM联合LOV治疗ACI疗效显著,值得推荐。

Objective To study the curative effect of Yinxingdamo and lovastatin on acute cerebral infarction and correlation of disabled degree after treatment with lipid levels.Methods All 122 acute cerebral infarction patients were randomly divided into two groups.The control group was treated with Yinxingdamo（YXDM）,the observation group was treated with YXDM and LOV.The whole blood viscosity,plasma viscosity,changes of TC,TG,HDL-C and LDL-C levels,curative effect of the two groups were compared,and the correlation of disabled degree after treatment with lipid levels were analyzed.Results Both groups after treatment of whole blood,plasma viscosity decreased significantly,and the whole blood viscosity decreased in the observation group than that in the control group.The TC,TG and LDL-C levels in the observation group after treatment were lower than those before treatment and the control group after treatment; HDL-C of the control group after treatment were higher than those before treatment.Total effective rate of the observation group was higher than that of the control group.The differences were statistically significant （P ＜ 0.05）.According to Spearman method analysis,the higher the degree of disability of patients after treatment was,the higher TC,TG and LDL-C levels respectively were,which were positively correlated （r =0.857,0.832,0.794; P =0.004,0.012,0.003）,however,HDL-C was lower,which were negatively correlated （r =-0.842,P =0.010）.Conclusions Yinxingdamo combined with lovastatin has good effect on patients with acute cerebral infarction.It is worthy to be recommended.