抗心磷脂抗体与复发性脑梗死关系研究

The relationship between anti-cardiolipin antibodies and recurrent cerebral infarction

目的研究血清抗心磷脂抗体(ACA)与复发性脑梗死的关系,为复发性脑梗死的预防和治疗提供依据。方法应用定量酶联免疫吸附实验(ELISA)对初发脑梗死组120例、复发性脑梗死组110例及正常对照组150人进行血清ACA检测与比较。结果复发脑梗死组ACA-IgG阳性率(31.82%)高于初发脑梗死组(15.00%)(P<0.05);脑梗死组和复发性脑梗死组ACA-IgG阳性率,年龄≤50岁者(57.89%)高于>50岁者(11.56%)(P<0.05);ACA-IgG阳性率女性(23.53%)与男性(22.52%)比较差异无统计学意义(P>0.05)。追踪随访1年初发脑梗死ACA-IgG阳性者复发率(56.25%)明显高于阴性者复发率(29.79%)(P<0.05)。结论复发性脑梗死患者血清ACA-IgG阳性率高,ACA-IgG阳性初发脑梗死患者复发率较高,ACA检测对于脑梗死的复发预测和临床早期干预具有重要意义。

Objective To explore the relationship between serum anti - cardiolipin antibodies（ ACA ） and recurrent cerebral infarction（ RCI）,and to provide the clinical evidence for the prevention and treatment of RCI. Methods One hundred and ten patients with RCI,120 patients with primary cerebral infarction（ PCI）and 150 healthy controls were recruited. Serum ACA was detected using quantitative enzyme linked immunosorbent assay（ ELISA）and the positive rate of ACA was compared between these three patient groups. Results The positive rate of serum ACA of RCI group （31. 82%）was higher than that of PCI group（ 15. 00%）（ P 〈0. 05 ）. Compared with patients above 50 years old （11. 56%）,the patients under age of 50 had a higher positive rate of ACA（ 57. 89%）（ P 〈0. 05 ）. There was no significant difference between males（ 22. 52%）and females（ 23. 53%） in positive rate of ACA（ P 〉 0. 05 ）. The recurrence rate（56. 25%）of ACA positive patients was higher than that of ACA negative patients（29. 79%）after one year follow up（P〈0. 05）. Conclusion Higher positive rate of serum ACA is observed in RCI patients. The PCI patients with high positive rate of serum ACA has an increased susceptibility for RCI. ACA detection is important for prediction and clinical intervention of the recurrence of cerebral infarction.