离子富集脉冲电源对提高飞行时间质谱仪灵敏度的影响

Effect of Ion Enrichment Pulse Power on Sensitivity Improvement of Time-of-flight Mass Spectrometry

研究自制离子富集脉冲电源对飞行时间质谱仪灵敏度的提高效果。离子富集脉冲电源包括脉冲信号产生模块、放大隔离模块、开关驱动模块、高压电路模块和负载阻抗匹配模块，输出一路中压脉冲信号，两路对称高压脉冲信号。利用自制电喷雾电离源及激光解析电离源与飞行时间质谱仪联用，调试中压脉冲信号。结果显示，应用离子富集脉冲电源后仪器对不同样品的检测灵敏度可提高6-24倍。

The effect of sensitivity enhancement of time-of-flight mass spectrometer（ TOF MS）was studied with home-made ion enrichment pulse power. lon enrichment pulse power includes pulse sig-nal generating module,amplification and isolation module,switching driving module,high voltage circuit module and load impedance matching module,outputing one medium voltage pulse signal and two-way symmetric high voltage pulse signals. ln this work,TOF MS with electrospray ionization （ ESl）was combined with laser desorption ionization（ LDl）to debug ion enrichment pulse power. As a conclusion,the detection sensitivity of the instrument could be increased by 6-24 times for differ-ent samples when applying ion enrichment pulse power.