金樱根、茎炮制品抗菌抗炎作用研究

Study on Antibacterial and Anti-inflammatory Effects of Different Processed Products of Rosa laevigata Root and Stem

目的:研究金樱根、茎不同炮制品的抗菌、急性抗炎及慢性抗炎作用,为其药材质量标准及其炮制品的临床使用提供依据。方法:金樱根、茎生品与炮制所得醋炙品、盐炙品、黑豆汁炙品及蜜炙品共10种样品水提取物,观察其对枯草芽孢杆菌、金黄色葡萄球菌等10种菌的抗菌作用;用二甲苯致小鼠耳廓肿胀试验研究急性抗炎能力;用小鼠棉球肉芽肿试验观察慢性抗炎作用。结果:金樱根炮制品的抑菌作用强于茎炮制品,尤其是金樱根蜜炙品抑菌作用明显;所有炮制品对二甲苯引起小鼠耳廓肿胀均无抑制作用;金樱根生品、茎盐炙品、茎蜜炙品和根蜜炙品对小鼠棉球肉芽肿的生成具有显著抑制作用。结论:金樱根蜜炙品有明显的抑菌作用和对小鼠慢性炎症的抗炎作用。

Objective:To study the anti-inflammatory and antibacterial effects of different processed products of Rosa laevigata root and stem. Methods:Different processed products were obtained from Rosa laevigata root and stem by frying with vinegar,salt,honey and black bean juice. Their antibacterial effect was observed on bacteria such as Bacillus subtilis,Staphylococcus aureus and Escherichia coli;The mice auricle swelling method was used in anti-inflammatory experiment by using xylene. The mice cotton granuloma method was used to observe the chronic inflammatory effect. Results:The antibacterial effects of processed products of Rosa laevigata root were better than that of the stem,especially the honey processed root. All processed products had no obvious effect on mouse auricular swelling. The raw root,salt processed stem,honey processed stem and honey processed root of Rosa laevigata had an inhibitory effect on cotton-pellet inducing mouse granuloma. Concllusion:The honey processed root of Rosa laevigata have significant antibacteral effect and anti-inflammatory effect on chronic infammation.