七氟烷对卵白蛋白致敏的高反应气道肺阻力的影响

Effect of Sevflurane on the Lung Resisitance in the Ovalbumin-sensitized Hyperresponsiveness Airways

目的观察七氟烷对卵白蛋白致敏的豚鼠高反应气道肺阻力的影响。方法 40只雄性豚鼠随机分为5组:正常组(N)、致敏组(S)、致敏对照组(SC)和致敏七氟烷组(包括SS1和SS2)。通过应用卵白蛋白和测量肺阻力变化曲线建立并评价豚鼠的致敏气道模型;根据致敏豚鼠对不同剂量乙酰胆碱刺激的肺阻力变化,评价七氟烷对高反应致敏气道的扩张作用。结果与N组相比,S组能显著升高豚鼠的肺阻力变化曲线;与SC组相比,SS1和SS2组的肺阻力明显下降。结论七氟烷能够降低卵白蛋白致敏豚鼠肺阻力,提示七氟烷对高反应致敏气道具有一定的扩张作用。

Objective To investigate the effects of sevoflurane on the lung resistance in a model of hyperresponsiveness airway using ovalbumin- sensitized guinea pigs. Methods Forty male guinea pigs were randomly divided into 5 groups ： normal group （N）, sensitized group （S）, sensitized control group （SC） and sensitized sevoflurane groups （SS1 and SS2 ）. The lung resisitance was recorded ; the dose-response curves for acetylchaline of lung resistance were used to evaluate the sensitized airway model and the brochodilator effect of sevoflurane. Results The dose-response curves for acetylcholine of lung resistance were significantly elevated in the S goup compared to the N group. The lung resistance were lower in SS1 and SS2 groups than group SC with an increase in acetylcholine concentration. Conclusion The use of sevoflurane could suppress the lung resisitance of sen- sitized guinea pigs, which suggested that sevoflurane may have a brochodilator effect in sensitized airways.