新生儿缺血缺氧性脑病的CT和MR表现分析及神经节苷脂联合高压氧治疗效果

Effect of hyperbaric oxygen combined with ganglioside in treatment of neonatal hypoxic ischemic encephalopathy and study the clinical value of CT scan

目的探讨新生儿缺血缺氧性脑病的CT和MR表现分析及神经节苷脂联合高压氧治疗效果。方法选取86例新生儿缺血缺氧性脑病患儿,随机分为神经节苷脂联合高压氧治疗组(简称观察组),以及常规治疗组(简称对照组),观察2组患儿的CT和MR表现,评价临床疗效。结果本研究中所有患儿脑实质内均出现局限或广泛低密度灶,表现为不同程度脑水肿,MR多表现为皮层、皮层下的T 1 W I条状、点状高信号影,观察组患儿有效率90.70%,优于对照组76.74%,差异具有统计学意义(P<0.05)。结论神经节苷脂联合高压氧治疗新生儿缺血缺氧性脑病疗效甚佳。

Objective To Effect of hyperbaric oxygen combined with ganglioside in treatment of neonatal hypoxic ischemic encephalopathy and study the clinical value of CT scan. Methods Divided randomly 86 cases of hypoxic ischemic encephalopathy into treatment group and control group. Give the treatment group hyperbaric oxygen combined with ganglioside treatment, Give the control group conventional treatment, Observed two groups of children with CT manifestations, clinical curative effect evaluation and NBNA score. Results All the children in this study are limited within the brain parenchyma or extensive low density foci,characterized by different degree of cerebral edema, observation group with effective rate was 90.70%, 76.74% better than the control group, the difference statistically significant（P〈0.05）. Conclusion Gangliosides and hyperbaric oxygen treatment of neonatal hypoxic ischemic encephalopathy could significantly improve nervous system dysfunction, for which it should be recommended in neonates department.