4项血常规参数对病毒性肝炎患者的临床意义

Value of four blood routine parameters in patients with viral hepatitis

目的探讨平均红细胞体积(MCV)、红细胞分布宽度(RDW)、血小板分布宽度(PDW)以及平均血小板体积(MPV)4项血常规参数对病毒性肝炎患者的临床意义。方法选取冀中能源峰峰集团公司总医院2010年12月至2012年12月病毒性肝炎患者376例为研究对象,依照患者的病情,将其分为急性肝炎组、慢性肝炎组、肝硬化组、重症肝炎组,同期选择32名健康人员作为对照组。利用全自动血细胞计数仪针对所有人员进行血常规参数的详细检测。并且在同一时间利用全自动生化分析仪对血清总胆红素(TBiL)以及清蛋白(ALB)进行检测。此外,利用全自动血凝仪对患者的血浆凝血酶原时间(PT)进行测定。结果慢性肝炎组、肝硬化组以及重症肝炎组患者RDW水平均高于对照组,差异有统计学意义(P<0.05)。慢性肝炎组及肝硬化组MCV水平均高于对照组,差异有统计学意义(P<0.05)。而慢性肝炎组、肝硬化组以及重症肝炎组与对照组PDW与MPV水平间比较,差异无统计学意义(P>0.05)。病毒性肝炎患者RDW与PT以及TBiL呈现正相关关系,但与ALB呈现负相关关系(P<0.05);且患者MCV与其PT水平呈现正相关关系,而与ALB呈现负相关关系。结论对MCV及RDW进行检测,能够有效反应病毒性肝炎患者肝脏病变程度,具有重大的临床意义。

Objective To evaluate the clinical significance of average red blood cell volume （MCV） ,red blood cell distribution width（RDW） ,platelet distribution width（PDW）and mean platelet volume（MPV）in patients with vi-ral hepatitis .Methods A total of 376 patietnts with viral hepatitis were selected as subjects in General Hospital of Jizhong Energy Fengfeng Group Company from Dec .2010 to Dec .2012 .The 376 cases were divided into acute hepati-tis group ,chronic hepatitis group ,cirrhosis group and severe hepatitis group according to the progress of disease . Other 32 healthy persons were recruited as control group .Automatic blood count meter was used to detect blood rou-tine parameters ,automatic biochemical analyzer was used to detect serum total bilirubin （TBiL）and albumin（ALB） .In addition ,automatic instrument of coagulation was used to determine plasma prothrombin time （PT ） .Results The RDW in the chronic hepatitis group ,cirrhosis group and severe hepatitis group was significant higher than that in the control group（P〈 0 .05） .The MCV in the chronic hepatitis group and cirrhosis group was significant higher than that in the control group（P〈 0 .05） .There were no significant differences on the M PV and PDW between the chronic hepatitis group ,cirrhosis group ,severe hepatitis group and the control group （P〉 0 .05） .For viral hepatitis patients , there were positive correlations between RDW and PT ,TBiL ,but the RDW and ALB had a negative correlation （P〈0 .05） .MCV and PT had positive correlation ,but the MCV and ALB had negative correlation （P〈 0 .05） .Conclusion MCV and RDW could effectively response the degree of liver lesion in patients with viral hepatitis .