去氧孕烯炔雌醇治疗围绝经期子宫异常出血的效果观察

Efficacy observation of ethinyl estradiol desogestrel in treatment of perimenopausal abnormal uterine bleeding

目的研究去氧孕烯炔雌醇治疗围绝经期子宫异常出血的临床效果。方法选取本院2012年3月-2013年5月确诊并收治的128例围绝经期子宫异常出血患者,将其随机分为研究组和对照组各64例。对照组患者应用米非司酮进行治疗,研究组患者应用去氧孕烯炔雌醇进行治疗。比照两组的疗效、止血效果及子宫内膜厚度变化,统计不良反应。结果研究组总有效率为95.31%,显著高于对照组的81.25%,差异有统计学意义（P〈0.05）。研究组出血缓解时间及止血时间显著短于对照组（P〈0.01）;治疗前两组子宫内膜厚度差异无统计学意义（P〉0.05）,治疗后两组子宫内膜厚度均显著变薄（P〈0.05）,且研究组变薄程度显著优于对照组（P〈0.01）。研究组不良反应发生率为1.56%,显著低于对照组的6.25%,差异有统计学意义（χ2=51.955,P〈0.01）。结论去氧孕烯炔雌醇治疗围绝经期子宫异常出血效果显著。

Objective To study the clinical effect of ethinyl estradiol desogestrel in the treatment of perimenopausal abnormal uterine bleeding. Methods 128 patients with perimenopausal abnormal uterine bleeding treated in our hospi-tal from March 2012 to May 2013 were selected and randomly divided into study group and control group,64 cases in each group.Mifepristone was given to the control group,ethinyl estradiol desogestrel was taken to the study group.The clinical effects,hemostatic effect and endometrial thickness changes of two groups were compared,adverse reactions were analyzed between the two groups. Results The total effective rate of study group was 95.31%,higher than 81.25% of the control group （P〈0.05）.Relieve bleeding time and bleeding time of study group was shorter than that of control group （P〈0.01）.The difference of endometrial thickness was not significant between the two groups before treatment （P〉0.05）, after treatment,the endometrial thickness of two groups was thinner （P〈0.05）,and the study group was thinner than that of the control group （P〈0.01）.The adverse reaction rate of study group was 1.56%,lower than 6.25%of the control group （P〈0.01）. Conclusion Ethinyl estradiol desogestrel in treatment of perimenopausal abnormal uterine bleeding has sig-nificant effects.